• Gene id: 10724

Gene Summary

• Gene Symbol: MGEA5   Gene   UCSC   Ensembl
• Aliases: MEA5, NCOAT, OGA
• Gene name: meningioma expressed antigen 5 (hyaluronidase)
• Alternate names: protein O-GlcNAcase, N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-glucosaminidase, O-GlcNAcase, beta-N-acetylglucosaminidase, beta-N-acetylhexosaminidase, beta-hexosaminidase, bifunctional protein NCOAT, hyaluronidase in meningioma, meningioma-expressed,
• Gene location: 10q24.32 (101818708: 101784442)     Exons: 17     NC_000010.11
• Gene summary(Entrez): The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-Gl
• OMIM: 604039

Protein Summary

• Protein general information: O60502  
  • Name: Protein O GlcNAcase (OGA) (EC 3.2.1.169) (Beta N acetylglucosaminidase) (Beta N acetylhexosaminidase) (Beta hexosaminidase) (Meningioma expressed antigen 5) (N acetyl beta D glucosaminidase) (N acetyl beta glucosaminidase) (Nuclear cytoplasmic O GlcNAcase
  • Length: 916  
  • Mass: 102,915
• Sequence:

  MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVM
  EQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKE
  VSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCY
  PNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
  TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYS
  PQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTT
  LTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIA
  PMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
  SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGD
  QEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDL
  IGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFH
  EEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
  KMEGFPKDVVILGRSL

• Structural information:
  • Interpro: IPR016181  IPR011496  IPR017853  
  • PDB: 2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX
  • PDBsum: 2YDQ 5M7R 5M7S 5M7T 5M7U 5TKE 5UHK 5UHL 5UHO 5UHP 5UN8 5UN9 5VVO 5VVT 5VVU 5VVV 5VVX
  • STRING: ENSP00000354850
• Other Databases: GeneCards:  MGEA5  Malacards:  MGEA5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004415	hyalurononglucosaminidase activity	TAS	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0006044	N-acetylglucosamine metabolic process	IDA	biological process
GO:0006516	glycoprotein catabolic process	TAS	biological process
GO:0006517	protein deglycosylation	IDA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0016231	beta-N-acetylglucosaminidase activity	IDA	molecular function
GO:0004415	hyalurononglucosaminidase activity	TAS	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0006044	N-acetylglucosamine metabolic process	IDA	biological process
GO:0006516	glycoprotein catabolic process	TAS	biological process
GO:0006517	protein deglycosylation	IDA	biological process
GO:0008152	metabolic process	IEA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0016231	beta-N-acetylglucosaminidase activity	IDA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	molecular function
GO:0004415	hyalurononglucosaminidase activity	TAS	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0006044	N-acetylglucosamine metabolic process	IDA	biological process
GO:0006516	glycoprotein catabolic process	TAS	biological process
GO:0006517	protein deglycosylation	IDA	biological process
GO:0016020	membrane	IDA	cellular component
GO:0016231	beta-N-acetylglucosaminidase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04931	Insulin resistance

Diseases

Associated diseases	References
Diabetes	GAD: 12359146
Male factor infertility	MIK: 10740715
Azoospermia	MIK: 1530367
Azoospermia	MIK: 1530367
Azoospermia	MIK: 1530367
Male infertility	MIK: 10740715
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
10740715	Male infertility				Male infertility
1530367	Azoopsermia			69 (8 normozoospermic controls, 7 secretory, and 54 excretory azoospermic subjects)	Male infertility
10740715	Male infertility				Male infertility	N-acetyl-beta-D-glucosaminidase
1530367	Azoospermia			69 subjects (8 normozoospermic controls, 7 secretory, and 54 excretory azoospermic subjects)	Male infertility	alpha-glucosidase alpha-mannosidase N-acetyl-beta-D-glucosaminidase
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray