Gene id |
1072 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
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Gene Symbol |
CFL1 Gene UCSC Ensembl |
Aliases |
CFL, HEL-S-15, cofilin |
Gene name |
cofilin 1 |
Alternate names |
cofilin-1, 18 kDa phosphoprotein, cofilin 1 (non-muscle), cofilin, non-muscle isoform, epididymis secretory protein Li 15, p18, |
Gene location |
11q13.1 (65858179: 65854672) Exons: 4 NC_000011.10
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Gene summary(Entrez) |
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distri
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OMIM |
601442 |
Protein Summary
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GO accession | Term name | Evidence code | Go category |
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Associated diseases |
References |
Neural tube defects | GAD: 17352815 |
Altered differentiation and/or maturation of endometrium | INFBASE: 25405865 |
Endometriosis | INFBASE: 22276910 |
Female infertility | INFBASE: 20713416 |
Endometriosis | INFBASE: 20646534 |
Unexplained infertility | INFBASE: 25405865 |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
Cryptorchidism | MIK: 28606200 |
Male factor infertility | MIK: 29961538 |
Sperm capacitation | MIK: 26085344 |
Acrosome reaction | MIK: 26085344 |
Teratozoospermia | MIK: 17327269 |
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PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
26085344 |
Sperm capa citation, Acrosome r eaction, Male infer tility
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Male infertility |
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Show abstract |
17327269 |
Teratozoos permia
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13 (5 controls, 8 cases)
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Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
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Show abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
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18
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Male infertility |
GSE26881
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Show abstract |
29961538 |
Male facto r infertil ity
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318 (128 couple s presenting wi th OAT (MF) and 118 maternal a ge-matched cont rol (no MF) sub jects undergoin g infertility t reatment, 72 su rplus cryoprese rved blastocyst s)
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Male infertility |
RNA-seq
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Show abstract |
28606200 |
Cryptorchi dism
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Monozgotic twin s (1 control, I cwith cryptorc hidism)
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Male infertility |
MeDIP-Seq
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Show abstract |
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