• Gene id: 1071

Gene Summary

• Gene Symbol: CETP   Gene   UCSC   Ensembl
• Aliases: BPIFF, HDLCQ10
• Gene name: cholesteryl ester transfer protein
• Alternate names: cholesteryl ester transfer protein, BPI fold containing family F, cholesteryl ester transfer protein plasma, lipid transfer protein I,
• Gene location: 16q13 (56961949: 56983844)     Exons: 17     NC_000016.10
• Gene summary(Entrez): The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcri
• OMIM: 612531

Protein Summary

• Protein general information: P11597  
  • Name: Cholesteryl ester transfer protein (Lipid transfer protein I)
  • Length: 493  
  • Mass: 54756
  • Tissue specificity: Expressed by the liver and secreted in plasma.
• Sequence:

  MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYG
  LHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDS
  GRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSD
  GDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
  MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHS
  VAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALM
  NSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

• Structural information:
  • Interpro: IPR017943  IPR017130  IPR001124  IPR017954  IPR017942  
  • Prosite: PS00400
  • PDB: 2OBD 4EWS 4F2A
  • PDBsum: 2OBD 4EWS 4F2A
  • STRING: ENSP00000200676
• Other Databases: GeneCards:  CETP  Malacards:  CETP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0034374	low-density lipoprotein particle remodeling	IBA	biological process
GO:0034364	high-density lipoprotein particle	IBA	cellular component
GO:0017129	triglyceride binding	IBA	molecular function
GO:0015485	cholesterol binding	IBA	molecular function
GO:0008203	cholesterol metabolic process	IBA	biological process
GO:0006641	triglyceride metabolic process	IBA	biological process
GO:0070328	triglyceride homeostasis	IBA	biological process
GO:0055091	phospholipid homeostasis	IBA	biological process
GO:0046470	phosphatidylcholine metabolic process	IBA	biological process
GO:0042632	cholesterol homeostasis	IBA	biological process
GO:0034375	high-density lipoprotein particle remodeling	IBA	biological process
GO:0034372	very-low-density lipoprotein particle remodeling	IBA	biological process
GO:0034197	triglyceride transport	IBA	biological process
GO:0031210	phosphatidylcholine binding	IBA	molecular function
GO:0005548	phospholipid transporter activity	IBA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0034197	triglyceride transport	IDA	biological process
GO:0030301	cholesterol transport	IDA	biological process
GO:0034375	high-density lipoprotein particle remodeling	IDA	biological process
GO:0034372	very-low-density lipoprotein particle remodeling	IDA	biological process
GO:0120020	cholesterol transfer activity	IDA	molecular function
GO:0008289	lipid binding	IEA	molecular function
GO:0043691	reverse cholesterol transport	IEA	biological process
GO:0034364	high-density lipoprotein particle	IEA	cellular component
GO:0120020	cholesterol transfer activity	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0008202	steroid metabolic process	IEA	biological process
GO:0006869	lipid transport	IEA	biological process
GO:0008203	cholesterol metabolic process	IEA	biological process
GO:0034374	low-density lipoprotein particle remodeling	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0034375	high-density lipoprotein particle remodeling	TAS	biological process
GO:0005548	phospholipid transporter activity	IDA	molecular function
GO:0008289	lipid binding	IDA	molecular function
GO:0031210	phosphatidylcholine binding	IDA	molecular function
GO:0015485	cholesterol binding	IDA	molecular function
GO:0120020	cholesterol transfer activity	IDA	molecular function
GO:0120020	cholesterol transfer activity	IDA	molecular function
GO:0017129	triglyceride binding	IDA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0010745	negative regulation of macrophage derived foam cell differentiation	IC	biological process
GO:0032376	positive regulation of cholesterol transport	IDA	biological process
GO:0034372	very-low-density lipoprotein particle remodeling	IDA	biological process
GO:0043691	reverse cholesterol transport	IC	biological process
GO:0046470	phosphatidylcholine metabolic process	IDA	biological process
GO:0055091	phospholipid homeostasis	IDA	biological process
GO:0070328	triglyceride homeostasis	IDA	biological process
GO:0034375	high-density lipoprotein particle remodeling	IMP	biological process
GO:0042632	cholesterol homeostasis	IMP	biological process
GO:0006641	triglyceride metabolic process	IDA	biological process
GO:0006869	lipid transport	IDA	biological process
GO:0008203	cholesterol metabolic process	IDA	biological process
GO:2001140	positive regulation of phospholipid transport	IDA	biological process
GO:0031982	vesicle	IDA	cellular component
GO:0034364	high-density lipoprotein particle	IDA	cellular component
GO:0034374	low-density lipoprotein particle remodeling	IDA	biological process
GO:0055088	lipid homeostasis	IDA	biological process
GO:0008203	cholesterol metabolic process	IMP	biological process
GO:0010874	regulation of cholesterol efflux	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0015914	phospholipid transport	IEA	biological process
GO:0015914	phospholipid transport	IEA	biological process
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0120009	intermembrane lipid transfer	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04979	Cholesterol metabolism
P06959	CCKR signaling map

Diseases

Associated diseases	References
Hyperalphalipoproteinemia	KEGG:H01199
Hyperalphalipoproteinemia	KEGG:H01199
Carotid artery disease	PMID:10619997
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881