• Gene id: 10695

Gene Summary

• Gene Symbol: CNPY3   Gene   UCSC   Ensembl
• Aliases: CAG4A, EIEE60, ERDA5, PRAT4A, TNRC5
• Gene name: canopy FGF signaling regulator 3
• Alternate names: protein canopy homolog 3, CAG repeat containing, CTG repeat protein 4a, expanded repeat-domain protein CAG/CTG 5, protein associated with TLR4, protein associated with Toll-like receptor 4A, trinucleotide repeat-containing gene 5 protein,
• Gene location: 6p21.1 (42928001: 42939293)     Exons: 8     NC_000006.12
• Gene summary(Entrez): This gene encodes a protein that binds members of the toll-like receptor protein family and functions as a chaperone to aid in folding and export of these proteins. Alternative splicing results in multiple transcript variants. Naturally occuring readthrou
• OMIM: 608416

Protein Summary

• Protein general information: Q9BT09  
  • Name: Protein canopy homolog 3 (CTG repeat protein 4a) (Expanded repeat domain protein CAG/CTG 5) (Protein associated with TLR4) (Trinucleotide repeat containing gene 5 protein)
  • Length: 278  
  • Mass: 30748
• Sequence:

  MDSMPEPASRCLLLLPLLLLLLLLLPAPELGPSQAGAEENDWVRLPSKCEVCKYVAVELKSAFEETGKTKEVIGT
  GYGILDQKASGVKYTKSDLRLIEVTETICKRLLDYSLHKERTGSNRFAKGMSETFETLHNLVHKGVKVVMDIPYE
  LWNETSAEVADLKKQCDVLVEEFEEVIEDWYRNHQEEDLTEFLCANHVLKGKDTSCLAEQWSGKKGDTAALGGKK
  SKKKSSRAKAAGGRSSSSKQRKELGGLEGDPSPEEDEGIQKASPLTHSPPDEL

• Structural information:
  • Protein Domains: (47..27-)
    (/note="Saposin-B-type")
  • Interpro: IPR021852  
  • STRING: ENSP00000361926
• Other Databases: GeneCards:  CNPY3  Malacards:  CNPY3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0045087	innate immune response	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0002224	toll-like receptor signaling pathway	TAS	biological process
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component

Diseases

Associated diseases	References
Early infantile epileptic encephalopathy	KEGG:H00606
Early infantile epileptic encephalopathy	KEGG:H00606
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881