• Gene id: 10645

Gene Summary

• Gene Symbol: CAMKK2   Gene   UCSC   Ensembl
• Aliases: CAMKK, CAMKKB
• Gene name: calcium/calmodulin dependent protein kinase kinase 2
• Alternate names: calcium/calmodulin-dependent protein kinase kinase 2, CAMKK beta protein, caM-KK 2, caM-KK beta, caM-kinase kinase 2, caM-kinase kinase beta, calcium/calmodulin-dependent protein kinase beta, calcium/calmodulin-dependent protein kinase kinase 2, beta,
• Gene location: 12q24.31 (121298307: 121237691)     Exons: 20     NC_000012.12
• Gene summary(Entrez): The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosph

Protein Summary

• Protein general information: Q96RR4  
  • Name: Calcium/calmodulin dependent protein kinase kinase 2 (CaM KK 2) (CaM kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin dependent protein kinase kinase beta) (CaM KK beta) (CaM kinase kinase beta) (CaMKK beta)
  • Length: 588  
  • Mass: 64746
  • Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung. {ECO
• Sequence:

  MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLE
  ADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHH
  VSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQ
  PRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
  EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWA
  MGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHG
  AEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREC
  ESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE

• Structural information:
  • Protein Domains: (165..44-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR011009  IPR000719  IPR017441  IPR008271  
  • Prosite: PS00107 PS50011 PS00108
  • PDB: 2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL
  • PDBsum: 2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL
  • STRING: ENSP00000312741
• Other Databases: GeneCards:  CAMKK2  Malacards:  CAMKK2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0061762	CAMKK-AMPK signaling cascade	IMP	biological process
GO:1903599	positive regulation of autophagy of mitochondrion	IC	biological process
GO:0005829	cytosol	IMP	cellular component
GO:0034614	cellular response to reactive oxygen species	TAS	biological process
GO:0001934	positive regulation of protein phosphorylation	IMP	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005516	calmodulin binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0016301	kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0004683	calmodulin-dependent protein kinase activity	IEA	molecular function
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0018108	peptidyl-tyrosine phosphorylation	IEA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0046777	protein autophosphorylation	IDA	biological process
GO:0005509	calcium ion binding	IDA	molecular function
GO:0045859	regulation of protein kinase activity	TAS	biological process
GO:0019722	calcium-mediated signaling	TAS	biological process
GO:0000165	MAPK cascade	TAS	biological process
GO:0045893	positive regulation of transcription, DNA-templated	TAS	biological process
GO:0005516	calmodulin binding	TAS	molecular function
GO:0004713	protein tyrosine kinase activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05034	Alcoholism
hsa04140	Autophagy - animal
hsa04921	Oxytocin signaling pathway
hsa04152	AMPK signaling pathway
hsa04211	Longevity regulating pathway
hsa04920	Adipocytokine signaling pathway

Diseases

Associated diseases	References
Malignant glioma	PMID:27012733
Cryptorchidism	MIK: 28606200
Male factor infertility	MIK: 29961538

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
29961538	Male factor infertility			318 (128 couples presenting with OAT (MF) and 118 maternal age-matched control (no MF) subjects undergoing infertility treatment, 72 surplus cryopreserved blastocysts)	Male infertility	RNA-seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq