• Gene id: 10625

Gene Summary

• Gene Symbol: IVNS1ABP   Gene   UCSC   Ensembl
• Aliases: ARA3, FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP
• Gene name: influenza virus NS1A binding protein
• Alternate names: influenza virus NS1A-binding protein, NCX downstream gene 1, NS1-binding protein, aryl hydrocarbon receptor-associated 3, aryl hydrocarbon receptor-associated protein 3, kelch-like family member 39, kelch-like protein 39,
• Gene location: 1q25.3 (185317291: 185292366)     Exons: 16     NC_000001.11
• OMIM: 609209

Protein Summary

• Protein general information: Q9Y6Y0  
  • Name: Influenza virus NS1A binding protein (NS1 BP) (NS1 binding protein) (Aryl hydrocarbon receptor associated protein 3) (Kelch like protein 39)
  • Length: 642  
  • Mass: 71729
• Sequence:

  MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF
  DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLL
  NKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYY
  SADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNN
  TYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGG
  YNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELR
  TNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNC
  LNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG
  IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF

• Structural information:
  • Protein Domains: (32..9-)
    (/note="BTB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00037-)
    (134..23-)
    (/note="BACK"-)
  • Interpro: IPR011705  IPR017096  IPR000210  IPR015915  IPR006652   IPR011333  
  • Prosite: PS50097
  • PDB: 5YY8 6N34 6N3H
  • PDBsum: 5YY8 6N34 6N3H
  • STRING: ENSP00000356468
• Other Databases: GeneCards:  IVNS1ABP  Malacards:  IVNS1ABP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0031397	negative regulation of protein ubiquitination	IMP	biological process
GO:0009615	response to virus	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0008380	RNA splicing	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0005667	transcription regulator complex	TAS	cellular component
GO:0008380	RNA splicing	TAS	biological process
GO:0005681	spliceosomal complex	TAS	cellular component
GO:0006383	transcription by RNA polymerase III	TAS	biological process
GO:0009615	response to virus	TAS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	IEA	biological process
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)