• Gene id: 10615

Gene Summary

• Gene Symbol: SPAG5   Gene   UCSC   Ensembl
• Aliases: DEEPEST, MAP126, hMAP126
• Gene name: sperm associated antigen 5
• Alternate names: sperm-associated antigen 5, astrin, mitotic spindle associated protein p126, mitotic spindle coiled-coil related protein,
• Gene location: 17q11.2 (28599024: 28577573)     Exons: 24     NC_000012.12
• Gene summary(Entrez): This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]
• OMIM: 615562

Diseases

Associated diseases	References
Cancer (breast)	GAD: 20508983
May cause a reduction in mitotic activity and an increase in apoptosis of fetal Sertoli cells in hgn/hgn testes	MIK: 17310077
Spermatogenesis defects	MIK: 11884588
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospermatogenesis	MIK: 28361989
May cause a reduction in mitotic activity and an increase in apoptosis of fetal Sertoli cells in hgn/hgn testes	MIK: 17310077
Non obstructive azoospermia	MIK: 23869807
Sertoli cell only syndrome	MIK: 23869807
Role in spermatogenesis	MIK: 11884588
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17310077	May cause a reduction in mitotic activity and an increase in apoptosis of fetal Sertoli cells in hgn/hgn testes				Male infertility
11884588	Role in spermatogenesis				Male infertility
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray