• Gene id: 10595

Gene Summary

• Gene Symbol: ERN2   Gene   UCSC   Ensembl
• Aliases: IRE1-BETA, IRE1b, IRE2p, hIRE2p
• Gene name: endoplasmic reticulum to nucleus signaling 2
• Alternate names: serine/threonine-protein kinase/endoribonuclease IRE2, ER to nucleus signalling 2, IRE1 beta, IRE1, S. cerevisiae, homolog of, endoplasmic reticulum to nucleus signalling 2, inositol-requiring 1 beta, inositol-requiring protein 2,
• Gene location: 16p12.2 (23713247: 23690309)     Exons: 24     NC_000016.10
• OMIM: 605915

Protein Summary

• Protein general information: Q76MJ5  
  • Name: Serine/threonine protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum to nucleus signaling 2) (Inositol requiring protein 2) (hIRE2p) (Ire1 beta) (IRE1b) [Includes: Serine/threonine protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26. )]
  • Length: 926  
  • Mass: 102480
• Sequence:

  MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMY
  VTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTE
  GPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDL
  GVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVS
  KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLR
  VHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFV
  MRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDV
  LGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQE
  YVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFS
  LHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHD
  KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHE
  HISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSC
  ASESLFLPYYPPDSEARRPCPGATGR

• Structural information:
  • Protein Domains: (520..78-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
    (784..91-)
    (/note="KEN-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00725"-)
  • Interpro: IPR033523  IPR010513  IPR038357  IPR011009  IPR018391   IPR000719  IPR018997  IPR011047  IPR008271  IPR015943  
  • Prosite: PS51392 PS50011 PS00108
  • STRING: ENSP00000256797
• Other Databases: GeneCards:  ERN2  Malacards:  ERN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0034976	response to endoplasmic reticulum stress	TAS	biological process
GO:1990604	IRE1-TRAF2-ASK1 complex	ISS	cellular component
GO:0004521	endoribonuclease activity	IBA	molecular function
GO:0005789	endoplasmic reticulum membrane	IBA	cellular component
GO:0030968	endoplasmic reticulum unfolded protein response	IBA	biological process
GO:0051082	unfolded protein binding	IBA	molecular function
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA	biological process
GO:0004672	protein kinase activity	IBA	molecular function
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0036498	IRE1-mediated unfolded protein response	IBA	biological process
GO:1990604	IRE1-TRAF2-ASK1 complex	IBA	cellular component
GO:0004540	ribonuclease activity	IEA	molecular function
GO:0004672	protein kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0006468	protein phosphorylation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016301	kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006915	apoptotic process	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0003824	catalytic activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA	biological process
GO:0007257	activation of JUN kinase activity	IEA	biological process
GO:0007050	cell cycle arrest	IEA	biological process
GO:1990604	IRE1-TRAF2-ASK1 complex	IEA	cellular component
GO:0034976	response to endoplasmic reticulum stress	IEA	biological process
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0006468	protein phosphorylation	IDA	biological process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0016075	rRNA catabolic process	IDA	biological process
GO:0005524	ATP binding	IDA	molecular function
GO:0004519	endonuclease activity	IDA	molecular function
GO:0000287	magnesium ion binding	IDA	molecular function
GO:0045892	negative regulation of transcription, DNA-templated	IMP	biological process
GO:0030263	apoptotic chromosome condensation	IMP	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq