• Gene id: 10570

Gene Summary

• Gene Symbol: DPYSL4   Gene   UCSC   Ensembl
• Aliases: CRMP3, DRP-4, ULIP4
• Gene name: dihydropyrimidinase like 4
• Alternate names: dihydropyrimidinase-related protein 4, CRMP-3, ULIP-4, UNC33-like phosphoprotein 4, collapsin response mediator protein 3,
• Gene location: 10q26.3 (132184982: 132205758)     Exons: 17     NC_000010.11
• OMIM: 604853

Protein Summary

• Protein general information: O14531  
  • Name: Dihydropyrimidinase related protein 4 (DRP 4) (Collapsin response mediator protein 3) (CRMP 3) (UNC33 like phosphoprotein 4) (ULIP 4)
  • Length: 572  
  • Mass: 61878
• Sequence:

  MSFQGKKSIPRITSDRLLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTR
  LQMPVLGMTPADDFCQGTKAALAGGTTMILDHVFPDTGVSLLAAYEQWRERADSAACCDYSLHVDITRWHESIKE
  ELEALVKEKGVNSFLVFMAYKDRCQCSDSQMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVL
  SHPEEVEAEAVYRAVTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGEPITASLGTDGSHYWSKNWAKAAA
  FVTSPPVNPDPTTADHLTCLLSSGDLQVTGSAHCTFTTAQKAVGKDNFALIPEGTNGIEERMSMVWEKCVASGKM
  DENEFVAVTSTNAAKIFNFYPRKGRVAVGSDADLVIWNPKATKIISAKTHNLNVEYNIFEGVECRGAPAVVISQG
  RVALEDGKMFVTPGAGRFVPRKTFPDFVYKRIKARNRLAEIHGVPRGLYDGPVHEVMVPAKPGSGAPARASCPGK
  ISVPPVRNLHQSGFSLSGSQADDHIARRTAQKIMAPPGGRSNITSLS

• Structural information:
  • Interpro: IPR006680  IPR030612  IPR011778  IPR011059  IPR032466  
  • CDD: cd01314
  • PDB: 5NKS
  • PDBsum: 5NKS
  • STRING: ENSP00000339850
• Other Databases: GeneCards:  DPYSL4  Malacards:  DPYSL4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004157	dihydropyrimidinase activity	IBA	NOT|molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0006208	pyrimidine nucleobase catabolic process	IBA	NOT|biological process
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0070997	neuron death	IEA	biological process
GO:0097485	neuron projection guidance	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0007399	nervous system development	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0031005	filamin binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq