Gene id |
10494 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
STK25 Gene UCSC Ensembl |
Aliases |
SOK1, YSK1 |
Gene name |
serine/threonine kinase 25 |
Alternate names |
serine/threonine-protein kinase 25, Ste20, yeast homolog, ste20-like kinase, ste20/oxidant stress response kinase 1, sterile 20/oxidant stress-response kinase 1, |
Gene location |
2q37.3 (14689786: 14733741) Exons: 19 NC_000019.10
|
Gene summary(Entrez) |
This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and m
|
OMIM |
602255 |
Protein Summary
|
Protein general information
| O00506
Name: Serine/threonine protein kinase 25 (EC 2.7.11.1) (Ste20 like kinase) (Sterile 20/oxidant stress response kinase 1) (SOK 1) (Ste20/oxidant stress response kinase 1)
Length: 426 Mass: 48112
Tissue specificity: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.
|
Sequence |
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS PYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSE QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLF LIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESS SEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQ SGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
|
Structural information |
|
Other Databases |
GeneCards: STK25 Malacards: STK25 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0031098 |
stress-activated protein kinase signaling cascade
|
IBA |
biological process |
GO:0023014 |
signal transduction by pr otein phosphorylation
|
IBA |
biological process |
GO:0032147 |
activation of protein kin ase activity
|
IBA |
biological process |
GO:0007346 |
regulation of mitotic cel l cycle
|
IBA |
biological process |
GO:0005737 |
cytoplasm
|
IBA |
cellular component |
GO:0004674 |
protein serine/threonine kinase activity
|
IBA |
molecular function |
GO:0051645 |
Golgi localization
|
IDA |
biological process |
GO:0042803 |
protein homodimerization activity
|
IDA |
molecular function |
GO:0004672 |
protein kinase activity
|
IEA |
molecular function |
GO:0005524 |
ATP binding
|
IEA |
molecular function |
GO:0006468 |
protein phosphorylation
|
IEA |
biological process |
GO:0046872 |
metal ion binding
|
IEA |
molecular function |
GO:0016740 |
transferase activity
|
IEA |
molecular function |
GO:0016301 |
kinase activity
|
IEA |
molecular function |
GO:0005794 |
Golgi apparatus
|
IEA |
cellular component |
GO:0005524 |
ATP binding
|
IEA |
molecular function |
GO:0016310 |
phosphorylation
|
IEA |
biological process |
GO:0000166 |
nucleotide binding
|
IEA |
molecular function |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0004674 |
protein serine/threonine kinase activity
|
IEA |
molecular function |
GO:0007165 |
signal transduction
|
TAS |
biological process |
GO:0004672 |
protein kinase activity
|
TAS |
molecular function |
GO:0006979 |
response to oxidative str ess
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0007163 |
establishment or maintena nce of cell polarity
|
IEA |
biological process |
GO:0006468 |
protein phosphorylation
|
IEA |
biological process |
GO:0000139 |
Golgi membrane
|
IEA |
cellular component |
GO:0051645 |
Golgi localization
|
IEA |
biological process |
GO:0050772 |
positive regulation of ax onogenesis
|
IEA |
biological process |
GO:0005794 |
Golgi apparatus
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0046777 |
protein autophosphorylati on
|
IDA |
biological process |
GO:0006468 |
protein phosphorylation
|
IDA |
biological process |
GO:0005794 |
Golgi apparatus
|
IDA |
colocalizes with |
GO:0042542 |
response to hydrogen pero xide
|
IDA |
biological process |
GO:0005737 |
cytoplasm
|
IDA |
cellular component |
GO:0032874 |
positive regulation of st ress-activated MAPK casca de
|
IDA |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0070062 |
extracellular exosome
|
HDA |
cellular component |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0090168 |
Golgi reassembly
|
IMP |
biological process |
GO:0051683 |
establishment of Golgi lo calization
|
IMP |
biological process |
GO:0036481 |
intrinsic apoptotic signa ling pathway in response to hydrogen peroxide
|
IGI |
biological process |
|
|
Associated diseases |
References |
Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
Cryptorchidism | MIK: 28606200 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
13 (5 controls, 8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
21674046 |
Aberrant C pGs in Low Motility Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
28606200 |
Cryptorchi dism
|
|
|
Monozgotic twin s (1 control, I cwith cryptorc hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|