• Gene id: 10407

Gene Summary

• Gene Symbol: SPAG11B   Gene   UCSC   Ensembl
• Aliases: EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11
• Gene name: sperm associated antigen 11B
• Alternate names: sperm-associated antigen 11B, epididymal protein 2B, human epididymis-specific protein 2, sperm antigen HE2,
• Gene location: 8p23.1 (7463669: 7447753)     Exons: 7     NC_000008.11
• Gene summary(Entrez): This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of simil
• OMIM: 606560

Protein Summary

• Protein general information: Q08648  
  • Name: Sperm associated antigen 11B (Human epididymis specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)
  • Length: 103  
  • Mass: 11,431
• Sequence:

  MRQRLLPSVTSLLLVALLFPGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQVHIS
  HREARGPSFRICVDFLGPRWARGCSTGN

• Structural information:
  • Interpro: IPR007988  
• Other Databases: GeneCards:  SPAG11B  Malacards:  SPAG11B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003674	molecular_function	ND	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0007283	spermatogenesis	TAS	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	NAS	cellular component
GO:0007283	spermatogenesis	TAS	biological process
GO:0003674	molecular_function	ND	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0007283	spermatogenesis	TAS	biological process

Diseases

Associated diseases	References
Oligoasthenoteratozoospermia	MIK: 24501866
Azoospermia	MIK: 24501866
Cryptorchidism	MIK: 28606200
Azoospermia	MIK: 24501866
Oligoasthenoteratozoospermia	MIK: 24501866

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24501866	Idiopathic azoospermia, oligoasthenoteratozoospermia			16 blood samples of men with an idiopathic oligoastenozoospermia or azoospermia	Male infertility	SPAG11B  SPAG11A EDDM3A and EDDM3B
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq