• Gene id: 10399

Gene Summary

• Gene Symbol: RACK1   Gene   UCSC   Ensembl
• Aliases: GNB2L1, Gnb2-rs1, H12.3, HLC-7, PIG21
• Gene name: receptor for activated C kinase 1
• Alternate names: receptor of activated protein C kinase 1, cell proliferation-inducing gene 21 protein, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, guanine nucleotide binding protein beta polypeptide 2-like 1, guanine nucleotide-binding protein ,
• Gene location: 5q35.3 (181243905: 181236896)     Exons: 8     NC_000005.10
• OMIM: 176981

Protein Summary

• Protein general information: P63244  
  • Name: Receptor of activated protein C kinase 1 (Cell proliferation inducing gene 21 protein) (Guanine nucleotide binding protein subunit beta 2 like 1) (Guanine nucleotide binding protein subunit beta like protein 12.3) (Human lung cancer oncogene 7 protein) (H
  • Length: 317  
  • Mass: 35077
  • Tissue specificity: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO
• Sequence:

  MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDG
  QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW
  VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK
  HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
  GYTDNLVRVWQVTIGTR

• Structural information:
  • Interpro: IPR020472  IPR015943  IPR001680  IPR019775  IPR017986   IPR036322  
  • Prosite: PS00678 PS50082 PS50294
  • PDB: 4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • DIP: 46736
  • STRING: ENSP00000426909
• Other Databases: GeneCards:  RACK1  Malacards:  RACK1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042803	protein homodimerization activity	IDA	molecular function
GO:0035591	signaling adaptor activity	IMP	molecular function
GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	IGI	biological process
GO:0071333	cellular response to glucose stimulus	IDA	biological process
GO:1990630	IRE1-RACK1-PP2A complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0033137	negative regulation of peptidyl-serine phosphorylation	IMP	biological process
GO:1900102	negative regulation of endoplasmic reticulum unfolded protein response	TAS	biological process
GO:0072344	rescue of stalled ribosome	IBA	biological process
GO:0043022	ribosome binding	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0005080	protein kinase C binding	IBA	molecular function
GO:0022627	cytosolic small ribosomal subunit	IBA	cellular component
GO:0019899	enzyme binding	IBA	molecular function
GO:0005634	nucleus	IBA	cellular component
GO:0001934	positive regulation of protein phosphorylation	IBA	biological process
GO:0071363	cellular response to growth factor stimulus	IDA	biological process
GO:0043022	ribosome binding	IDA	molecular function
GO:0072344	rescue of stalled ribosome	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0042998	positive regulation of Golgi to plasma membrane protein transport	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0016567	protein ubiquitination	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0048511	rhythmic process	IEA	biological process
GO:0042995	cell projection	IEA	cellular component
GO:0005840	ribosome	IEA	cellular component
GO:0006417	regulation of translation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0040008	regulation of growth	IEA	biological process
GO:0006915	apoptotic process	IEA	biological process
GO:0007369	gastrulation	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	TAS	biological process
GO:2000304	positive regulation of ceramide biosynthetic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006412	translation	IEA	biological process
GO:0030425	dendrite	IEA	cellular component
GO:0043005	neuron projection	IEA	cellular component
GO:0044297	cell body	IEA	cellular component
GO:1903208	negative regulation of hydrogen peroxide-induced neuron death	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0008200	ion channel inhibitor activity	IEA	molecular function
GO:0043025	neuronal cell body	IEA	cellular component
GO:0043473	pigmentation	IEA	biological process
GO:0045296	cadherin binding	HDA	molecular function
GO:0019899	enzyme binding	IPI	molecular function
GO:0060090	molecular adaptor activity	TAS	molecular function
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity	IMP	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0043204	perikaryon	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0001891	phagocytic cup	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0048471	perinuclear region of cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0061099	negative regulation of protein tyrosine kinase activity	IEA	biological process
GO:0051726	regulation of cell cycle	IDA	biological process
GO:0031334	positive regulation of protein-containing complex assembly	IDA	biological process
GO:0005080	protein kinase C binding	IDA	molecular function
GO:0043547	positive regulation of GTPase activity	IDA	biological process
GO:0030971	receptor tyrosine kinase binding	IDA	molecular function
GO:0030496	midbody	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	biological process
GO:0030335	positive regulation of cell migration	IDA	biological process
GO:0030308	negative regulation of cell growth	IDA	biological process
GO:0001891	phagocytic cup	IDA	cellular component
GO:0043065	positive regulation of apoptotic process	IDA	biological process
GO:0042169	SH2 domain binding	IDA	molecular function
GO:0042169	SH2 domain binding	IDA	molecular function
GO:0030292	protein tyrosine kinase inhibitor activity	IDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0001934	positive regulation of protein phosphorylation	IDA	biological process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological process
GO:0051434	BH3 domain binding	IDA	molecular function
GO:0032091	negative regulation of protein binding	IDA	biological process
GO:0051898	negative regulation of protein kinase B signaling	IMP	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0043025	neuronal cell body	ISS	cellular component
GO:0032880	regulation of protein localization	ISS	biological process
GO:0030178	negative regulation of Wnt signaling pathway	ISS	biological process
GO:0019903	protein phosphatase binding	IPI	molecular function
GO:0015935	small ribosomal subunit	ISS	cellular component
GO:0005739	mitochondrion	IMP	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005102	signaling receptor binding	NAS	molecular function
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	IMP	biological process
GO:0051901	positive regulation of mitochondrial depolarization	IMP	biological process
GO:0030425	dendrite	ISS	cellular component
GO:0005829	cytosol	IMP	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:2000543	positive regulation of gastrulation	ISS	biological process
GO:2000114	regulation of establishment of cell polarity	ISS	biological process
GO:0050765	negative regulation of phagocytosis	IMP	biological process
GO:0017148	negative regulation of translation	ISS	biological process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	biological process
GO:0051302	regulation of cell division	ISS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0043065	positive regulation of apoptotic process	IMP	biological process
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	IMP	molecular function
GO:0008200	ion channel inhibitor activity	ISS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0010629	negative regulation of gene expression	IMP	biological process
GO:0030332	cyclin binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05162	Measles

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881