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Gene id |
103910 |
| Gene Summary Protein Summary KEGG pathways Diseases PubMed |
Gene Summary
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Gene Symbol |
MYL12B Gene UCSC Ensembl |
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Aliases |
MLC-B, MRLC2 |
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Gene name |
myosin light chain 12B |
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Alternate names |
myosin regulatory light chain 12B, MLC-2, MLC-2A, MLC20, SHUJUN-1, myosin regulatory light chain 2, myosin regulatory light chain 2-B, smooth muscle isoform, myosin regulatory light chain 20 kDa, myosin regulatory light chain MRLC2, myosin, light chain 12B, regula, |
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Gene location |
18p11.31 (7936186: 7919229) Exons: 10 NC_000012.12
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Gene summary(Entrez) |
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [
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OMIM |
609211 |
Protein Summary
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| Associated diseases |
References |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Teratozoospermia | MIK: 17327269 |
|
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| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 17327269 |
Teratozoos
permia
|
|
|
13 (5 controls,
8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|