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Gene id 10352
Gene Summary    Protein Summary    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol WARS2   Gene   UCSC   Ensembl
Aliases NEMMLAS, TrpRS, mtTrpRS
Gene name tryptophanyl tRNA synthetase 2, mitochondrial
Alternate names tryptophan--tRNA ligase, mitochondrial, (Mt)TrpRS, tryptophan tRNA ligase 2, mitochondrial,
Gene location 1p12 (119140787: 119031215)     Exons: 8     NC_000001.11
Gene summary(Entrez) Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first prot
OMIM 604733

Protein Summary

Protein general information Q9UGM6  

Name: Tryptophan tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl tRNA synthetase) (TrpRS)

Length: 360  Mass: 40147

Tissue specificity: Brain. {ECO

Sequence MALHSMRKARERWSFIRALHKGSAAAPALQKDSKKRVFSGIQPTGILHLGNYLGAIESWVRLQDEYDSVLYSIVD
LHSITVPQDPAVLRQSILDMTAVLLACGINPEKSILFQQSQVSEHTQLSWILSCMVRLPRLQHLHQWKAKTTKQK
HDGTVGLLTYPVLQAADILLYKSTHVPVGEDQVQHMELVQDLAQGFNKKYGEFFPVPESILTSMKKVKSLRDPSA
KMSKSDPDKLATVRITDSPEEIVQKFRKAVTDFTSEVTYDPAGRAGVSNIVAVHAAVTGLSVEEVVRRSAGMNTA
RYKLAVADAVIEKFAPIKREIEKLKLDKDHLEKVLQIGSAKAKELAYTVCQEVKKLVGFL
Structural information
Interpro:  IPR001412  IPR002305  IPR014729  IPR002306  IPR024109  
Prosite:   PS00178
CDD:   cd00806

PDB:  
5EKD
PDBsum:   5EKD
STRING:   ENSP00000235521
Other Databases GeneCards:  WARS2  Malacards:  WARS2

KEGG pathways

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Pathway idPathway name
hsa00970Aminoacyl-tRNA biosynthesis
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract