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Gene id 10320
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary
Gene Symbol IKZF1   Gene   UCSC   Ensembl
Aliases CVID13, Hs.54452, IK1, IKAROS, LYF1, LyF-1, PPP1R92, PRO0758, ZNFN1A1
Gene name IKAROS family zinc finger 1
Alternate names DNA-binding protein Ikaros, CLL-associated antigen KW-6, ikaros family zinc finger protein 1, lymphoid transcription factor LyF-1, protein phosphatase 1, regulatory subunit 92, zinc finger protein, subfamily 1A, 1 (Ikaros),
Gene location 7p12.2 (50303452: 50405100)     Exons: 15     NC_000007.14
Gene summary(Entrez) This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions a
OMIM 603023

Protein Summary
Protein general information Q13422  

Name: DNA binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF 1)

Length: 519  Mass: 57528

Tissue specificity: Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. {ECO

Sequence MDADEGQDMSQVSGKESPPVSDTPDEGDEPMPIPEDLSTTSGGQQSSKSDRVVASNVKVETQSDEENGRACEMNG
EECAEDLRMLDASGEKMNGSHRDQGSSALSGVGGIRLPNGKLKCDICGIICIGPNVLMVHKRSHTGERPFQCNQC
GASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHN
YLESMGLPGTLYPVIKEETNHSEMAEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFLGDKGLSDTPYDSSASYE
KENEMMKSHVMDQAINNAINYLGAESLRPLVQTPPGGSEVVPVISPMYQLHKPLAEGTPRSNHSAQDSAVENLLL
LSKAKLVPSEREASPSNSCQDSTDTESNNEEQRSGLIYLTNHIAPHARNGLSLKEEHRAYDLLRAASENSQDALR
VVSTSGEQMKVYKCEHCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEHRFHMS
Structural information
Interpro:  IPR036236  IPR013087  
Prosite:   PS00028 PS50157

PDB:  		 6H0F
PDBsum:   6H0F

DIP:  
41110
MINT:  
STRING:   ENSP00000331614
Other Databases GeneCards:  IKZF1  Malacards:  IKZF1

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0005654 nucleoplasm
 IBA cellular component
GO:0003700 DNA-binding transcription
factor activity
 IBA molecular function
GO:0000978 RNA polymerase II cis-reg
ulatory region sequence-s
pecific DNA binding
 IBA molecular function
GO:0000976 transcription regulatory
region sequence-specific
DNA binding
 IBA molecular function
GO:0045944 positive regulation of tr
anscription by RNA polyme
rase II
 IBA biological process
GO:0000977 RNA polymerase II transcr
iption regulatory region
sequence-specific DNA bin
ding
 IBA molecular function
GO:0003677 DNA binding
 IDA molecular function
GO:0005634 nucleus
 IDA cellular component
GO:0003677 DNA binding
 IDA molecular function
GO:0031618 nuclear pericentric heter
ochromatin
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0045892 negative regulation of tr
anscription, DNA-template
d
 ISS biological process
GO:0030098 lymphocyte differentiatio
n
 IMP biological process
GO:0030218 erythrocyte differentiati
on
 IMP biological process
GO:0046872 metal ion binding
 IEA molecular function
GO:0006325 chromatin organization
 IEA biological process
GO:0005737 cytoplasm
 IEA cellular component
GO:0007049 cell cycle
 IEA biological process
GO:0007275 multicellular organism de
velopment
 IEA biological process
GO:0005634 nucleus
 IEA cellular component
GO:0003677 DNA binding
 IEA molecular function
GO:0003677 DNA binding
 TAS molecular function
GO:0007498 mesoderm development
 TAS biological process
GO:0032991 protein-containing comple
x
 IDA cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005634 nucleus
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0032991 protein-containing comple
x
 IMP cellular component
GO:0005515 protein binding
 IPI molecular function
GO:0019904 protein domain specific b
inding
 IPI molecular function

Diseases

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Associated diseases References
Common variable immunodeficiency KEGG:H00088
Common variable immunodeficiency KEGG:H00088
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
13 (5 controls,
8 cases)
 Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract