• Gene id: 10298

Gene Summary

• Gene Symbol: PAK4   Gene   UCSC   Ensembl
• Gene name: p21 (RAC1) activated kinase 4
• Alternate names: serine/threonine-protein kinase PAK 4, p21 protein (Cdc42/Rac)-activated kinase 4, p21(CDKN1A)-activated kinase 4, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs,
• Gene location: 19q13.2 (39125785: 39182815)     Exons: 14     NC_000019.10
• Gene summary(Entrez): PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP b

Protein Summary

• Protein general information: O96013  
  • Name: Serine/threonine protein kinase PAK 4 (EC 2.7.11.1) (p21 activated kinase 4) (PAK 4)
  • Length: 591  
  • Mass: 64072
  • Tissue specificity: Highest expression in prostate, testis and colon.
• Sequence:

  MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSK
  GAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGD
  RRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPH
  DVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
  HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH
  ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH
  DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMK
  MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR

• Structural information:
  • Protein Domains: (11..2-)
    (/note="CRIB-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00057-)
    (321..57-)
    (/note="Protein-kinase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"-)
  • Interpro: IPR000095  IPR036936  IPR011009  IPR033923  IPR000719   IPR017441  
  • Prosite: PS50108 PS00107 PS50011
  • CDD: cd01093
  • PDB: 2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW
  • PDBsum: 2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW
  • DIP: 39742
  • STRING: ENSP00000469413
• Other Databases: GeneCards:  PAK4  Malacards:  PAK4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0023014	signal transduction by protein phosphorylation	IBA	biological process
GO:0031098	stress-activated protein kinase signaling cascade	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0007346	regulation of mitotic cell cycle	IBA	biological process
GO:0032147	activation of protein kinase activity	IBA	biological process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular function
GO:0016477	cell migration	TAS	biological process
GO:0001558	regulation of cell growth	TAS	biological process
GO:0007165	signal transduction	TAS	biological process
GO:0007010	cytoskeleton organization	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006915	apoptotic process	TAS	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0006468	protein phosphorylation	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0004674	protein serine/threonine kinase activity	IEA	molecular function
GO:0006915	apoptotic process	IEA	biological process
GO:0016310	phosphorylation	IEA	biological process
GO:0007049	cell cycle	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0004672	protein kinase activity	NAS	molecular function
GO:0005794	Golgi apparatus	TAS	cellular component
GO:0007165	signal transduction	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0060996	dendritic spine development	IEA	biological process
GO:0071407	cellular response to organic cyclic compound	IEA	biological process
GO:0004672	protein kinase activity	IEA	molecular function
GO:0098641	cadherin binding involved in cell-cell adhesion	HDA	molecular function
GO:0004674	protein serine/threonine kinase activity	IMP	molecular function
GO:0005912	adherens junction	HDA	cellular component
GO:2000352	negative regulation of endothelial cell apoptotic process	IMP	biological process
GO:0045766	positive regulation of angiogenesis	IMP	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0098609	cell-cell adhesion	IEA	biological process
GO:0005925	focal adhesion	HDA	cellular component
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05206	MicroRNAs in cancer
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04510	Focal adhesion
hsa04360	Axon guidance
hsa05170	Human immunodeficiency virus 1 infection
hsa04660	T cell receptor signaling pathway
hsa04012	ErbB signaling pathway
hsa05211	Renal cell carcinoma

Diseases

Associated diseases	References
clear cell renal cell carcinoma	PMID:25744653
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq