• Gene id: 10289

Gene Summary

• Gene Symbol: EIF1B   Gene   UCSC   Ensembl
• Aliases: GC20
• Gene name: eukaryotic translation initiation factor 1B
• Alternate names: eukaryotic translation initiation factor 1b, protein translation factor SUI1 homolog GC20, translation factor sui1 homolog,
• Gene location: 3p22.1 (40309706: 40312423)     Exons: 4     NC_000003.12
• OMIM: 0

Protein Summary

• Protein general information: O60739  
  • Name: Eukaryotic translation initiation factor 1b (eIF1b) (Protein translation factor SUI1 homolog GC20)
  • Length: 113  
  • Mass: 12824
• Sequence:

  MSTIQNLQSFDPFADATKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIE
  HPEYGEVIQLQGDQRKNICQFLLEVGIVKEEQLKVHGF

• Structural information:
  • Interpro: IPR001950  IPR036877  IPR005874  
  • Prosite: PS50296
  • CDD: cd11566
  • STRING: ENSP00000232905
• Other Databases: GeneCards:  EIF1B  Malacards:  EIF1B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0016282	eukaryotic 43S preinitiation complex	IBA	cellular component
GO:0003723	RNA binding	IBA	molecular function
GO:0043024	ribosomal small subunit binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006446	regulation of translational initiation	NAS	biological process
GO:0003723	RNA binding	HDA	molecular function
GO:0005575	cellular_component	ND	cellular component

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881