• Gene id: 10267

Gene Summary

• Gene Symbol: RAMP1   Gene   UCSC   Ensembl
• Gene name: receptor activity modifying protein 1
• Alternate names: receptor activity-modifying protein 1, CRLR activity-modifying protein 1, calcitonin receptor-like receptor activity modifying protein 1, receptor (G protein-coupled) activity modifying protein 1, receptor (calcitonin) activity modifying protein 1,
• Gene location: 2q37.3 (237858554: 237912113)     Exons: 7     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytop
• OMIM: 604829

Protein Summary

• Protein general information: O60894  
  • Name: Receptor activity modifying protein 1 (Calcitonin receptor like receptor activity modifying protein 1) (CRLR activity modifying protein 1)
  • Length: 148  
  • Mass: 16988
  • Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract. {ECO
• Sequence:

  MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWH
  MAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV

• Structural information:
  • Interpro: IPR006985  IPR038126  
  • PDB: 2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y
  • PDBsum: 2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y
  • DIP: 37675
  • STRING: ENSP00000254661
• Other Databases: GeneCards:  RAMP1  Malacards:  RAMP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005623	obsolete cell	IDA	cellular component
GO:0150056	amylin receptor complex 1	IDA	cellular component
GO:0097643	amylin receptor activity	IGI	contributes to
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	biological process
GO:0097647	amylin receptor signaling pathway	IGI	biological process
GO:0072659	protein localization to plasma membrane	IBA	biological process
GO:0043235	receptor complex	IBA	cellular component
GO:0006816	calcium ion transport	IBA	biological process
GO:0001525	angiogenesis	IBA	biological process
GO:0032870	cellular response to hormone stimulus	IBA	biological process
GO:0031623	receptor internalization	IBA	biological process
GO:0015031	protein transport	IBA	biological process
GO:0015026	coreceptor activity	IBA	molecular function
GO:0009986	cell surface	IBA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IBA	biological process
GO:0008277	regulation of G protein-coupled receptor signaling pathway	IEA	biological process
GO:0006886	intracellular protein transport	IEA	biological process
GO:0015026	coreceptor activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005887	integral component of plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0032092	positive regulation of protein binding	IEA	biological process
GO:0015026	coreceptor activity	IEA	molecular function
GO:0031623	receptor internalization	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0015026	coreceptor activity	IEA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0072659	protein localization to plasma membrane	IDA	biological process
GO:0006816	calcium ion transport	IDA	biological process
GO:1990406	CGRP receptor complex	IDA	cellular component
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0005886	plasma membrane	IDA	colocalizes with
GO:0097647	amylin receptor signaling pathway	IDA	biological process
GO:0060050	positive regulation of protein glycosylation	IDA	biological process
GO:0043235	receptor complex	IDA	cellular component
GO:0001525	angiogenesis	IDA	biological process
GO:1990406	CGRP receptor complex	IDA	cellular component
GO:0015031	protein transport	IDA	biological process
GO:0031623	receptor internalization	IDA	biological process
GO:0001635	calcitonin gene-related peptide receptor activity	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1990408	calcitonin gene-related peptide receptor signaling pathway	IPI	biological process
GO:0097643	amylin receptor activity	IPI	molecular function
GO:0001635	calcitonin gene-related peptide receptor activity	IPI	molecular function
GO:0001635	calcitonin gene-related peptide receptor activity	IPI	molecular function
GO:1990407	calcitonin gene-related peptide binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI	biological process
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI	biological process
GO:1990408	calcitonin gene-related peptide receptor signaling pathway	IPI	biological process

KEGG pathways

Pathway id	Pathway name
hsa04270	Vascular smooth muscle contraction

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq