Gene id |
10220 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
GDF11 Gene UCSC Ensembl |
Aliases |
BMP-11, BMP11 |
Gene name |
growth differentiation factor 11 |
Alternate names |
growth/differentiation factor 11, GDF-11, bone morphogenetic protein 11, |
Gene location |
12q13.2 (55743121: 55757263) Exons: 3 NC_000012.12
|
Gene summary(Entrez) |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate
|
OMIM |
603936 |
Protein Summary
|
Protein general information
| O95390
Name: Growth/differentiation factor 11 (GDF 11) (Bone morphogenetic protein 11) (BMP 11)
Length: 407 Mass: 45091
|
Sequence |
MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELR LESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETD PAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLK IELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPT KMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
|
Structural information |
|
Other Databases |
GeneCards: GDF11 Malacards: GDF11 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0060395 |
SMAD protein signal trans duction
|
IBA |
biological process |
GO:0005615 |
extracellular space
|
IBA |
cellular component |
GO:0005125 |
cytokine activity
|
IBA |
molecular function |
GO:0010862 |
positive regulation of pa thway-restricted SMAD pro tein phosphorylation
|
IBA |
biological process |
GO:0060395 |
SMAD protein signal trans duction
|
IMP |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0008083 |
growth factor activity
|
IEA |
molecular function |
GO:0005125 |
cytokine activity
|
IEA |
molecular function |
GO:0005615 |
extracellular space
|
IEA |
cellular component |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0008083 |
growth factor activity
|
IEA |
molecular function |
GO:0032991 |
protein-containing comple x
|
IDA |
cellular component |
GO:0001501 |
skeletal system developme nt
|
IEA |
biological process |
GO:0001656 |
metanephros development
|
IEA |
biological process |
GO:0001657 |
ureteric bud development
|
IEA |
biological process |
GO:0005615 |
extracellular space
|
IEA |
cellular component |
GO:0008285 |
negative regulation of ce ll population proliferati on
|
IEA |
biological process |
GO:0009887 |
animal organ morphogenesi s
|
IEA |
biological process |
GO:0009952 |
anterior/posterior patter n specification
|
IEA |
biological process |
GO:0045596 |
negative regulation of ce ll differentiation
|
IEA |
biological process |
GO:0060395 |
SMAD protein signal trans duction
|
IEA |
biological process |
GO:0045665 |
negative regulation of ne uron differentiation
|
IEA |
biological process |
GO:0021512 |
spinal cord anterior/post erior patterning
|
IEA |
biological process |
GO:0031016 |
pancreas development
|
IEA |
biological process |
GO:0048469 |
cell maturation
|
IEA |
biological process |
GO:0048593 |
camera-type eye morphogen esis
|
IEA |
biological process |
GO:0060021 |
roof of mouth development
|
IEA |
biological process |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005654 |
nucleoplasm
|
IDA |
cellular component |
GO:0043231 |
intracellular membrane-bo unded organelle
|
IDA |
cellular component |
GO:0001501 |
skeletal system developme nt
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0007498 |
mesoderm development
|
TAS |
biological process |
GO:0007399 |
nervous system developmen t
|
TAS |
biological process |
|
|
Pathway id | Pathway name |
hsa04060 | Cytokine-cytokine receptor interaction | |
|
Associated diseases |
References |
Cryptorchidism | MIK: 28606200 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
13 (5 controls, 8 cases)
|
Male infertility |
GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
17327269 |
Teratozoos permia
|
|
|
19 (6 controls , 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
28606200 |
Cryptorchi dism
|
|
|
Monozgotic twin s (1 control, I cwith cryptorc hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|