• Gene id: 10209

Gene Summary

• Gene Symbol: EIF1   Gene   UCSC   Ensembl
• Aliases: A121, EIF-1, EIF1A, ISO1, SUI1
• Gene name: eukaryotic translation initiation factor 1
• Alternate names: eukaryotic translation initiation factor 1, protein translation factor SUI1 homolog, sui1iso1,
• Gene location: 17q21.2 (41688884: 41692667)     Exons: 4     NC_000017.11

Protein Summary

• Protein general information: P41567  
  • Name: Eukaryotic translation initiation factor 1 (eIF1) (A121) (Protein translation factor SUI1 homolog) (Sui1iso1)
  • Length: 113  
  • Mass: 12732
• Sequence:

  MSAIQNLHSFDPFADASKGDDLLPAGTEDYIHIRIQQRNGRKTLTTVQGIADDYDKKKLVKAFKKKFACNGTVIE
  HPEYGEVIQLQGDQRKNICQFLVEIGLAKDDQLKVHGF

• Structural information:
  • Interpro: IPR001950  IPR036877  IPR005874  
  • Prosite: PS50296
  • CDD: cd11566
  • PDB: 2IF1 4KZX 4KZY
  • PDBsum: 2IF1 4KZX 4KZY
  • DIP: 50783
  • STRING: ENSP00000419449
• Other Databases: GeneCards:  EIF1  Malacards:  EIF1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006446	regulation of translational initiation	IDA	biological process
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0016282	eukaryotic 43S preinitiation complex	IBA	cellular component
GO:0003723	RNA binding	IBA	molecular function
GO:0043024	ribosomal small subunit binding	IBA	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0006413	translational initiation	IEA	biological process
GO:0003743	translation initiation factor activity	TAS	molecular function
GO:0008135	translation factor activity, RNA binding	TAS	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0006446	regulation of translational initiation	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0009048	dosage compensation by inactivation of X chromosome	IEA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003743	translation initiation factor activity	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)