• Gene id: 10208

Gene Summary

• Gene Symbol: USPL1   Gene   UCSC   Ensembl
• Aliases: C13orf22, D13S106E, bA121O19.1
• Gene name: ubiquitin specific peptidase like 1
• Alternate names: SUMO-specific isopeptidase USPL1, USP-like 1, highly charged protein, ubiquitin-specific peptidase-like protein 1,
• Gene location: 13q12.3 (30617858: 30660765)     Exons: 10     NC_000013.11
• OMIM: 617470

Protein Summary

• Protein general information: Q5W0Q7  
  • Name: SUMO specific isopeptidase USPL1 (EC 3.4.22. ) (Ubiquitin specific peptidase like protein 1) (USP like 1)
  • Length: 1092  
  • Mass: 120440
• Sequence:

  MMDSPKIGNGLPVIGPGTDIGISSLHMVGYLGKNFDSAKVPSDEYCPACREKGKLKALKTYRISFQESIFLCEDL
  QCIYPLGSKSLNNLISPDLEECHTPHKPQKRKSLESSYKDSLLLANSKKTRNYIAIDGGKVLNSKHNGEVYDETS
  SNLPDSSGQQNPIRTADSLERNEILEADTVDMATTKDPATVDVSGTGRPSPQNEGCTSKLEMPLESKCTSFPQAL
  CVQWKNAYALCWLDCILSALVHSEELKNTVTGLCSKEESIFWRLLTKYNQANTLLYTSQLSGVKDGDCKKLTSEI
  FAEIETCLNEVRDEIFISLQPQLRCTLGDMESPVFAFPLLLKLETHIEKLFLYSFSWDFECSQCGHQYQNRHMKS
  LVTFTNVIPEWHPLNAAHFGPCNNCNSKSQIRKMVLEKVSPIFMLHFVEGLPQNDLQHYAFHFEGCLYQITSVIQ
  YRANNHFITWILDADGSWLECDDLKGPCSERHKKFEVPASEIHIVIWERKISQVTDKEAACLPLKKTNDQHALSN
  EKPVSLTSCSVGDAASAETASVTHPKDISVAPRTLSQDTAVTHGDHLLSGPKGLVDNILPLTLEETIQKTASVSQ
  LNSEAFLLENKPVAENTGILKTNTLLSQESLMASSVSAPCNEKLIQDQFVDISFPSQVVNTNMQSVQLNTEDTVN
  TKSVNNTDATGLIQGVKSVEIEKDAQLKQFLTPKTEQLKPERVTSQVSNLKKKETTADSQTTTSKSLQNQSLKEN
  QKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGFKTKGINQKASHVSKKARKSASKPPPI
  SKPPAGPPSSNGTAAHPHAHAASEVLEKSGSTSCGAQLNHSSYGNGISSANHEDLVEGQIHKLRLKLRKKLKAEK
  KKLAALMSSPQSRTVRSENLEQVPQDGSPNDCESIEDLLNELPYPIDIASESACTTVPGVSLYSSQTHEEILAEL
  LSPTPVSTELSENGEGDFRYLGMGDSHIPPPVPSEFNDVSQNTHLRQDHNYCSPTKKNPCEVQPDSLTNNACVRT
  LNLESPMKTDIFDEFFSSSALNALANDTLDLPHFDEYLFENY

• Structural information:
  • Protein Domains: (227..50-)
    (/note="USP"-)
  • Interpro: IPR029388  IPR038765  IPR028890  IPR028889  IPR033505  
  • Prosite: PS50235
  • DIP: 47278
  • STRING: ENSP00000255304
• Other Databases: GeneCards:  USPL1  Malacards:  USPL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032183	SUMO binding	IBA	molecular function
GO:0016926	protein desumoylation	IBA	biological process
GO:0070140	SUMO-specific isopeptidase activity	IBA	molecular function
GO:0030576	Cajal body organization	IBA	biological process
GO:0015030	Cajal body	IBA	cellular component
GO:0032183	SUMO binding	IDA	molecular function
GO:0016926	protein desumoylation	IDA	biological process
GO:0070140	SUMO-specific isopeptidase activity	IDA	molecular function
GO:0043130	ubiquitin binding	IDA	NOT|molecular function
GO:0015030	Cajal body	IDA	cellular component
GO:0015030	Cajal body	IDA	cellular component
GO:0009301	snRNA transcription	IMP	biological process
GO:0030576	Cajal body organization	IMP	biological process
GO:0008283	cell population proliferation	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0032183	SUMO binding	IEA	molecular function
GO:0030576	Cajal body organization	IEA	biological process
GO:0070140	SUMO-specific isopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0008234	cysteine-type peptidase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0015030	Cajal body	IEA	cellular component
GO:0005615	extracellular space	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)