• Gene id: 10197

Gene Summary

• Gene Symbol: PSME3   Gene   UCSC   Ensembl
• Aliases: HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
• Gene name: proteasome activator subunit 3
• Alternate names: proteasome activator complex subunit 3, 11S regulator complex gamma subunit, 11S regulator complex subunit gamma, Ki antigen, Ki nuclear autoantigen, PA28 gamma variant 5, REG gamma-3, activator of multicatalytic protease subunit 3, epididymis secretory protein L,
• Gene location: 17q21.31 (42833141: 42843759)     Exons: 12     NC_000067.6
• Gene summary(Entrez): The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits a
• OMIM: 605129

KEGG pathways

Pathway id	Pathway name
hsa04612	Antigen processing and presentation
hsa05160	Hepatitis C
hsa05160	Hepatitis C
hsa04612	Antigen processing and presentation
hsa03050	Proteasome

Diseases

Associated diseases	References
Male factor infertility	MIK: 27003159
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male infertility	MIK: 27003159
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27003159	Male infertility				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881