• Gene id: 10135

Gene Summary

• Gene Symbol: NAMPT   Gene   UCSC   Ensembl
• Aliases: 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
• Gene name: nicotinamide phosphoribosyltransferase
• Alternate names: nicotinamide phosphoribosyltransferase, NAmPRTase, pre-B cell-enhancing factor, pre-B-cell colony-enhancing factor 1,
• Gene location: 7q22.3 (106284982: 106248297)     Exons: 11     NC_000007.14
• Gene summary(Entrez): This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic
• OMIM: 608764

Protein Summary

• Protein general information: P43490  
  • Name: Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre B cell colony enhancing factor 1) (Pre B cell enhancing factor) (Visfatin)
  • Length: 491  
  • Mass: 55521
  • Tissue specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
• Sequence:

  MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVV
  TKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIET
  ILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLA
  LIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
  SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSI
  ENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDL
  EEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH

• Structural information:
  • Interpro: IPR013785  IPR041529  IPR041525  IPR016471  IPR036068  
  • CDD: cd01569
  • PDB: 2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB
  • PDBsum: 2E5B 2E5C 2E5D 2GVG 2GVJ 3DGR 3DHD 3DHF 3DKJ 3DKL 4JNM 4JR5 4KFN 4KFO 4KFP 4L4L 4L4M 4LTS 4LV9 4LVA 4LVB 4LVD 4LVF 4LVG 4LWW 4M6P 4M6Q 4N9B 4N9C 4N9D 4N9E 4O0Z 4O10 4O12 4O13 4O14 4O15 4O16 4O17 4O18 4O19 4O1A 4O1B 4O1C 4O1D 4O28 4WQ6 5KIT 5LX3 5LX5 5NSD 5U2M 5U2N 5UPE 5UPF 5WI0 5WI1 6ATB 6AZJ 6B75 6B76 6E68 6PEB
  • DIP: 29218
  • STRING: ENSP00000222553
• Other Databases: GeneCards:  NAMPT  Malacards:  NAMPT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032922	circadian regulation of gene expression	ISS	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	molecular function
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0005125	cytokine activity	IEA	molecular function
GO:0048511	rhythmic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0019363	pyridine nucleotide biosynthetic process	IEA	biological process
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0005615	extracellular space	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005125	cytokine activity	TAS	molecular function
GO:0007165	signal transduction	TAS	biological process
GO:0007267	cell-cell signaling	TAS	biological process
GO:0008284	positive regulation of cell population proliferation	TAS	biological process
GO:0047280	nicotinamide phosphoribosyltransferase activity	IEA	molecular function
GO:0007623	circadian rhythm	TAS	biological process
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway	TAS	biological process
GO:0047280	nicotinamide phosphoribosyltransferase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1904646	cellular response to amyloid-beta	IEA	biological process
GO:0090650	cellular response to oxygen-glucose deprivation	IEA	biological process
GO:0014916	regulation of lung blood pressure	IEA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0007568	aging	IEA	biological process
GO:0007565	female pregnancy	IEA	biological process
GO:0005125	cytokine activity	IEA	molecular function
GO:0047280	nicotinamide phosphoribosyltransferase activity	IEA	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0032922	circadian regulation of gene expression	IEA	biological process
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0007623	circadian rhythm	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:2000773	negative regulation of cellular senescence	IEA	biological process
GO:1905377	response to D-galactose	IEA	biological process
GO:0071479	cellular response to ionizing radiation	IEA	biological process
GO:0070997	neuron death	IEA	biological process
GO:0048661	positive regulation of smooth muscle cell proliferation	IEA	biological process
GO:0047280	nicotinamide phosphoribosyltransferase activity	IEA	molecular function
GO:0042802	identical protein binding	IEA	molecular function
GO:0010507	negative regulation of autophagy	IEA	biological process
GO:0008144	drug binding	IEA	molecular function
GO:0007623	circadian rhythm	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0001774	microglial cell activation	IEA	biological process
GO:0008286	insulin receptor signaling pathway	IDA	NOT|biological process
GO:0060612	adipose tissue development	IDA	NOT|biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	IDA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0016607	nuclear speck	IDA	cellular component
GO:0030054	cell junction	IDA	cellular component
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04621	NOD-like receptor signaling pathway
hsa00760	Nicotinate and nicotinamide metabolism

Diseases

Associated diseases	References
Transient cerebral ischemia	PMID:25603815
Coronary artery disease	PMID:17283255
Carotid artery disease	PMID:17283255
Pulmonary hypertension	PMID:28202489
type 2 diabetes mellitus	PMID:18410550
type 2 diabetes mellitus	PMID:16234302
obesity	PMID:17618961
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R