• Gene id: 100996939

Gene Summary

• Gene Symbol: PYURF   Gene   UCSC   Ensembl
• Aliases: PREY
• Gene name: PIGY upstream reading frame
• Alternate names: protein preY, mitochondrial, PIGY upstream reading frame protein,
• Gene location: 4q22.1 (88523775: 88520997)     Exons: 2     NC_000004.12
• Gene summary(Entrez): The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the ups

Protein Summary

• Protein general information: Q96I23  
  • Name: Protein preY, mitochondrial (PIGY upstream reading frame protein)
  • Length: 114  
  • Mass: 12655
• Sequence:

  MLSGARCRLASALRGTRAPPSAVARRCLHASGSRPLADRGKKTEEPPRDFDPALLEFLVCPLSKKPLRYEASTNE
  LINEELGIAYPIIDGIPNMIPQAARMTRQSKKQEEVEQR

• Structural information:
  • Protein Domains: (51..9-)
    (/note="TRM112"-)
  • Interpro: IPR005651  
  • STRING: ENSP00000273968
• Other Databases: GeneCards:  PYURF  Malacards:  PYURF

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006506	GPI anchor biosynthetic process	IMP	biological process
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	cellular component
GO:0005789	endoplasmic reticulum membrane	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0009893	positive regulation of metabolic process	IMP	biological process
GO:0006506	GPI anchor biosynthetic process	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA	cellular component
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IEA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)