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Gene id 10092
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary

Gene Symbol ARPC5   Gene   UCSC   Ensembl
Aliases ARC16, dJ127C7.3, p16-Arc
Gene name actin related protein 2/3 complex subunit 5
Alternate names actin-related protein 2/3 complex subunit 5, Arp2/3 protein complex subunit p16, actin related protein 2/3 complex, subunit 5, 16kDa, arp2/3 complex 16 kDa subunit,
Gene location 1q25.3 (94148576: 94307674)     Exons: 35     NC_000012.12
Gene summary(Entrez) This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by
OMIM 604227

Protein Summary

Protein general information O15511  

Name: Actin related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16 ARC)

Length: 151  Mass: 16320

Sequence MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRA
GSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKT
V
Structural information
Interpro:  IPR006789  IPR036743  

DIP:  

33144

STRING:   ENSP00000294742
Other Databases GeneCards:  ARPC5  Malacards:  ARPC5

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0016477 cell migration
IMP biological process
GO:0034314 Arp2/3 complex-mediated a
ctin nucleation
IBA biological process
GO:0016477 cell migration
IBA biological process
GO:0005885 Arp2/3 protein complex
IBA cellular component
GO:0005737 cytoplasm
IBA cellular component
GO:0035861 site of double-strand bre
ak
ISS cellular component
GO:0005634 nucleus
ISS cellular component
GO:0005885 Arp2/3 protein complex
IEA cellular component
GO:0015629 actin cytoskeleton
IEA cellular component
GO:0034314 Arp2/3 complex-mediated a
ctin nucleation
IEA biological process
GO:0030833 regulation of actin filam
ent polymerization
IEA biological process
GO:0042995 cell projection
IEA cellular component
GO:0003779 actin binding
IEA molecular function
GO:0005737 cytoplasm
IEA cellular component
GO:0005856 cytoskeleton
IEA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0005200 structural constituent of
cytoskeleton
TAS molecular function
GO:0005885 Arp2/3 protein complex
TAS cellular component
GO:0015629 actin cytoskeleton
TAS cellular component
GO:0030036 actin cytoskeleton organi
zation
TAS biological process
GO:0005737 cytoplasm
TAS cellular component
GO:0051015 actin filament binding
IDA contributes to
GO:0005200 structural constituent of
cytoskeleton
IDA molecular function
GO:0005885 Arp2/3 protein complex
IDA cellular component
GO:0034314 Arp2/3 complex-mediated a
ctin nucleation
IDA biological process
GO:0043312 neutrophil degranulation
TAS biological process
GO:1904813 ficolin-1-rich granule lu
men
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005576 extracellular region
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0005829 cytosol
TAS cellular component
GO:0034774 secretory granule lumen
TAS cellular component
GO:0038096 Fc-gamma receptor signali
ng pathway involved in ph
agocytosis
TAS biological process
GO:0048013 ephrin receptor signaling
pathway
TAS biological process
GO:0061024 membrane organization
TAS biological process
GO:0005768 endosome
IEA cellular component
GO:0014909 smooth muscle cell migrat
ion
IEA biological process
GO:0030011 maintenance of cell polar
ity
IEA biological process
GO:0043005 neuron projection
IEA cellular component
GO:0061842 microtubule organizing ce
nter localization
IEA biological process
GO:0097581 lamellipodium organizatio
n
IEA biological process
GO:0021769 orbitofrontal cortex deve
lopment
IEA biological process
GO:0030426 growth cone
IEA cellular component
GO:0051639 actin filament network fo
rmation
IEA biological process
GO:0030027 lamellipodium
IEA cellular component
GO:0005856 cytoskeleton
IEA cellular component
GO:0005634 nucleus
IEA cellular component
GO:0042995 cell projection
IEA cellular component
GO:0005515 protein binding
IPI molecular function
GO:0070062 extracellular exosome
HDA cellular component
GO:0070062 extracellular exosome
HDA cellular component
GO:0005925 focal adhesion
HDA cellular component

KEGG pathways

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Pathway idPathway name
hsa04144Endocytosis
hsa05131Shigellosis
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection
hsa05130Pathogenic Escherichia coli infection
hsa04666Fc gamma R-mediated phagocytosis
hsa05100Bacterial invasion of epithelial cells
Associated diseases References
lung squamous cell carcinoma PMID:22089643
lung non-small cell carcinoma PMID:22089643
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

13 (5 controls,
8 cases)
Male infertility GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract