• Gene id: 10076

Gene Summary

• Gene Symbol: PTPRU   Gene   UCSC   Ensembl
• Aliases: FMI, PCP-2, PTP, PTP-J, PTP-PI, PTP-RO, PTPPSI, PTPRO, PTPU2, R-PTP-PSI, R-PTP-U, hPTP-J
• Gene name: protein tyrosine phosphatase receptor type U
• Alternate names: receptor-type tyrosine-protein phosphatase U, PTP pi, Receptor protein tyrosine phosphatase hPTP-J, pancreatic carcinoma phosphatase 2, pi R-PTP-Psi, protein-tyrosine phosphatase J, protein-tyrosine phosphatase pi, protein-tyrosine phosphatase receptor omicron, r,
• Gene location: 1p35.3 (29236521: 29326801)     Exons: 33     NC_000001.11
• Gene summary(Entrez): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
• OMIM: 602454

Protein Summary

• Protein general information: Q92729  
  • Name: Receptor type tyrosine protein phosphatase U (R PTP U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP 2) (Protein tyrosine phosphatase J) (PTP J) (hPTP J) (Protein tyrosine phosphatase pi) (PTP pi) (Protein tyrosine phosphatase receptor omicron)
  • Length: 1446  
  • Mass: 162423
  • Tissue specificity: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in b
• Sequence:

  MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVN
  TSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAV
  STFWPNEYQVLFEALISPDRRGYMGLDDILLLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQ
  RQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
  YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLI
  SRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
  KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQ
  SIESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
  LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARGLVHYFGAELAASSLP
  EAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILG
  ICAGGLAVLILLLGAIIVIIRKGRDHYAYSYYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLS
  FMDTHGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
  FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRM
  VWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTA
  WPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRV
  NMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
  PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM
  LNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDT
  PDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVET
  MDQYHFCYDVALEYLEGLESR

• Structural information:
  • Protein Domains: (25..18-)
    (/note="MAM-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00128-)
    (190..27-)
    (/note="Ig-like-C2-type)
    (288..38-)
    1 (/note="Fibronectin-type-III)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00316-)
    (386..48-)
    (/note="Fibro-)
  • Interpro: IPR013320  IPR003961  IPR036116  IPR036179  IPR013783   IPR000998  IPR029021  IPR000242  IPR016130  IPR003595  IPR000387  
  • Prosite: PS50853 PS00740 PS50060 PS00383 PS50056 PS50055
  • CDD: cd00063 cd06263
  • STRING: ENSP00000334941
• Other Databases: GeneCards:  PTPRU  Malacards:  PTPRU

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004725	protein tyrosine phosphatase activity	IBA	molecular function
GO:0006470	protein dephosphorylation	IBA	biological process
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0006470	protein dephosphorylation	IEA	biological process
GO:0016311	dephosphorylation	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016791	phosphatase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0030154	cell differentiation	IEA	biological process
GO:0004721	phosphoprotein phosphatase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0007155	cell adhesion	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0004725	protein tyrosine phosphatase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0051384	response to glucocorticoid	IEA	biological process
GO:0008013	beta-catenin binding	IEA	molecular function
GO:0031100	animal organ regeneration	IEA	biological process
GO:0034109	homotypic cell-cell adhesion	IEA	biological process
GO:0030054	cell junction	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0035335	peptidyl-tyrosine dephosphorylation	IEA	biological process
GO:0090090	negative regulation of canonical Wnt signaling pathway	IDA	biological process
GO:0034394	protein localization to cell surface	IDA	biological process
GO:0006470	protein dephosphorylation	IDA	biological process
GO:0005911	cell-cell junction	IDA	cellular component
GO:0004725	protein tyrosine phosphatase activity	IDA	molecular function
GO:0030336	negative regulation of cell migration	IDA	biological process
GO:0030336	negative regulation of cell migration	IDA	biological process
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin	IDA	biological process
GO:0008285	negative regulation of cell population proliferation	IDA	biological process
GO:0005887	integral component of plasma membrane	NAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0008013	beta-catenin binding	IPI	molecular function
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	NAS	biological process
GO:0007155	cell adhesion	NAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	NAS	molecular function
GO:0004725	protein tyrosine phosphatase activity	IMP	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq