• Gene id: 10038

Gene Summary

• Gene Symbol: PARP2   Gene   UCSC   Ensembl
• Aliases: ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
• Gene name: poly(ADP-ribose) polymerase 2
• Alternate names: poly [ADP-ribose] polymerase 2, ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2, ADP-ribosyltransferase diphtheria toxin-like 2, ADPRT-2, NAD(+) ADP-ribosyltransferase 2, hPARP-2, poly (ADP-ribose) polymerase family, member 2, poly (ADP-,
• Gene location: 14q11.2 (20343040: 20357903)     Exons: 16     NC_000014.9
• Gene summary(Entrez): This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transfer
• OMIM: 607725

Protein Summary

• Protein general information: Q9UGN5  
  • Name: Poly [ADP ribose] polymerase 2 (PARP 2) (hPARP 2) (EC 2.4.2.30) (ADP ribosyltransferase diphtheria toxin like 2) (ARTD2) (NAD(+) ADP ribosyltransferase 2) (ADPRT 2) (Poly[ADP ribose] synthase 2) (pADPRT 2)
  • Length: 583  
  • Mass: 66,206
• Sequence:

  MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWA
  SKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMR
  WGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLK
  SPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
  ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHE
  SYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEA
  PITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSS
  AHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW

• Structural information:
  • Protein Domains: PARP (231-348)
    PARP (356-583)
  • Interpro: IPR012317  IPR004102  IPR036616  IPR036930  IPR008893  
  • Prosite: PS51060 PS51059
  • PDB: 3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY
  • PDBsum: 3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY
  • DIP: 48934
  • STRING: ENSP00000250416
• Other Databases: GeneCards:  PARP2  Malacards:  PARP2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003677	DNA binding	IEA	molecular function
GO:0003910	DNA ligase (ATP) activity	IBA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006273	lagging strand elongation	IBA	biological process
GO:0006281	DNA repair	TAS	biological process
GO:0006284	base-excision repair	IEA	biological process
GO:0006471	protein ADP-ribosylation	IEA	biological process
GO:0051103	DNA ligation involved in DNA repair	IBA	biological process
GO:0097191	extrinsic apoptotic signaling pathway	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0003910	DNA ligase (ATP) activity	IBA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0003950	NAD+ ADP-ribosyltransferase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IEA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006273	lagging strand elongation	IBA	biological process
GO:0006281	DNA repair	TAS	biological process
GO:0006284	base-excision repair	IEA	biological process
GO:0006471	protein ADP-ribosylation	IEA	biological process
GO:0006471	protein ADP-ribosylation	TAS	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0051103	DNA ligation involved in DNA repair	IBA	biological process
GO:0097191	extrinsic apoptotic signaling pathway	IEA	biological process
GO:0003910	DNA ligase (ATP) activity	IBA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0006273	lagging strand elongation	IBA	biological process
GO:0006281	DNA repair	TAS	biological process
GO:0006471	protein ADP-ribosylation	TAS	biological process
GO:0051103	DNA ligation involved in DNA repair	IBA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04210	Apoptosis
hsa04217	Necroptosis

Diseases

Associated diseases	References
Cancer (epithelial ovarian)	GAD: 19064572
Cancer	GAD: 19064572
Multiple sclerosis	GAD: 20522537
Meiotic arrest	MIK: 19806447
Azoospermia	MIK: 19806447
Chronic renal failure	GAD: 21085059
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Associated with sperm cell apoptosis	MIK: 18339380
Azoospermia, meiotic arrest	MIK: 19806447
Contributes to the fidelity of male meiosis I and spermiogenesis	MIK: 17001008
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
19806447	Azoospermia, meiotic arrest	LMTK2(381 C/G:Pro/Ala, 2371T/C Ile/Thr, 2631T/A Leu/Met, 2726G/A Synonymous GA, 2726G/A Synonymous GA, 3164C/T Synonymous CT, 3641G/A Synonymous GA, 4145A/G Synonymous AG, 5277T/C 3?UTR TC ), PARP (1159C/T Synonymous, 1359G/A Arg/Gln, 1469A/C Asn/His, 178	Japanes e	18 Japanese men with azoospermia	Male infertility	LMTK2 PARP-2
18339380	Associated with sperm cell apoptosis			30 (18 healthy donors, 12 infertile males)	Male infertility
17001008	Contributes to the fidelity of male meiosis I and spermiogenesis				Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881