• PMID: 8579761
• Gene Name: PGR
• Condition: luteal phase defect (LPD)
• Association: Associated
• Sex: male
• Infertility type: Male infertility
• Associated genes: PR
• Other associated phenotypes: luteal phase defect (LPD)

Decreased expression of endometrial decay accelerating factor (DAF), a complement regulatory protein, in patients with luteal phase defect

Kaul A, Nagamani M, Nowicki B.

PROBLEM: We investigated the level of decay accelerating factor (DAF) in the endometrium of luteal phase defect (LPD) patients, before and after treatment with progesterone. METHODS: Endometrial samples from fourteen normal-cycling controls and six samples from infertility patients with LPD before and four samples after progesterone treatment were stained by anti-DAF IgG using immunohistochemistry. RESULTS: Mean DAF OD in LPD patients was 15% compared to 60% in the control group. The mean DAF OD was 88% after treatment with progesterone. CONCLUSION: Results support interpretation that progesterone upregulates DAF while decreased progesterone may be associated with reduced expression of the DAF in LPD patients. FAU - Kaul, A AU - Kaul A AD - Department of Obstetrics & Gynecology, University of Texas Medical Branch at Galveston 77555-1062, USA. FAU - Nagamani, M AU - Nagamani M