• PMID: 22724438
• Gene Name: PIP
• Condition: Azoospermia, Oligozoospermia
• Association: Associated
• Sex: Male
• Infertility type: Male infertility
• Associated genes: PIP
• Other associated phenotypes: Azoospermia, Oligozoospermia

Quantification studies in human seminal plasma samples identify prolactin inducible protein as a plausible marker of azoospermia

Tomar AK, Sooch BS, Singh S, Yadav S.

BACKGROUND: Prolactin inducible protein (PIP) is a ~17 kDa protein, which is known to play vital roles in immunoregulation, fertility, antimicrobial activity, apoptosis and tumour progression. OBJECTIVES: This study reports quantification of PIP concentration in human seminal plasma (SP) samples. METHODOLOGY: PIP was purified by immunoprecipitation and its concentration in human SP samples was quantified by ELISA method. RESULTS: Average concentration of PIP in normozoospermia, oligozoospermia and azoospermia was 290.3 ± 71.5 µg/mL, 306.4 ± 71.2 µg/mL and 60.5 ± 23.6 µg/mL respectively. CONCLUSION: There was no significant variation in PIP levels in normozoospermia and oligozoospermia while its expression was down-regulated in azoospermia, indicating that PIP may be a plausible marker of azoospermia. FAU - Tomar, Anil Kumar AU - Tomar AK AD - Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. FAU - Sooch, Balwinder Singh AU - Sooch BS FAU - Singh, Sarman AU - Singh S