• PMID: 21348202
• Gene Name: CR16
• Condition: Idiopathic azoospermia
• Association: Associated
• Population size: 58
• Population details: 58 (48 patients with idiopathic azoospermia, 10 healthy men)
• Sex: Male
• Infertility type: Male infertility
• Associated genes: CR16
• Other associated phenotypes: Idiopathic azoospermia

[Expression of CR16 in the testis of patients with idiopathic azoospermia]

Wen ZN, Pang WJ, Xiang WP.

OBJECTIVE: To investigate the expression of corticosteroids and regional expression 16 (CR16) in the testis of patients with idiopathic azoospermia and the role of CR16 in spermatogenesis. METHODS: Immunohistochemistry and RT-PCR were used to detect the expression levels of the CR16 protein and mRNA in the testes of 48 patients with idiopathic azoospermia and 10 healthy men. RESULTS: Immunohistochemistry showed that the CR16 protein expressed in the Sertoli cells and spermatids-binding region in the epithelium of seminiferous tubules. The level of the CR16 protein was markedly lower in the idiopathic azoospermia patients than in the healthy men, and RT-PCR also showed a significantly decreased level of CR16 mRNA in the testis of the patients. CONCLUSION: The expressions of the CR16 protein and mRNA decrease markedly in the testis of patients with idiopathic azoospermia, indicating a correlation with the pathogenesis of azoospermia. FAU - Wen, Zi-Na AU - Wen ZN AD - Family Planning Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. youth1111youth@sohu.com FAU - Pang, Wen-Juan AU - Pang WJ