• PMID: 19947564
• Gene Name: AR
• Condition: Male infertility
• Association: The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis.
• Mutation: (CAG)n polymorphism
• Population size: 5467
• Population details: 5467 (3,153 idiopathic infertile men, 2,314 controls)
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Male infertility

[Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis]

Li Y, Wang LA, Wu TX.

OBJECTIVE: To assess the association of male infertility with CAG repeat polymorphism of the androgen receptor (AR) gene by meta-analysis. METHODS: We identified the case-control studies on the relationship of male infertility with CAG repeats of the AR gene by searching Medline/PubMed and CBM databases, and conducted meta-analysis on the data obtained with the RevMan 4.2 software. RESULTS: Thirty-two eligible articles were selected in this study, including 3,153 idiopathic infertile men and 2,314 controls. The combined data statistics showed that all the infertile men had a significantly higher mean of CAG repeats than the controls (SMD = 0.27, 95% CI: 0.17-0.37, P < 0.01). The specific SMD between the infertile patients and controls was 0.29, 95% CI: 0.08-0.50 for the azoospermic men, 0.27, 95% CI: 0.13-0.41 for the moderate oligozoospermic men, and 0.18, 95% CI: 0.02-0.33 for the severe oligozoospermic cases. The results of sensitivity analyses were consistent with those mentioned above. CONCLUSION: The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis. FAU - Li, Ya AU - Li Y AD - Department of Biochemistry and Molecular Biology, Chengdu Medical College, Chengdu, Sichuan 610081, China. FAU - Wang, Lun-an AU - Wang LA