• PMID: 18155199
• Gene Name: BRCA1
• Condition: Female Infertility, Oligoasthenoteratospermia
• Association: A modified natural IVF cycle is an effective and safe solution for BRCA1 or BRCA2 mutation gene carrier women with couple infertility.
• Mutation: BRCA1(c.5382insc exon 20 codon 1755)
• Population size: 1
• Population details: 1 women with infertility
• Age: 26 yrs
• Sex: Male, Female
• Infertility type: Male infertility, Female infertility
• Other associated phenotypes: Female Infertility, Oligoasthenoteratospermia

Pregnancy after in vitro fertilization-intracytoplasmic sperm injection obtained with a modified natural cycle in a BRCA1 mutation carrier

Hirt R, Davy C, Guibert J, Olivennes F.

OBJECTIVE: To report a successful pregnancy after a semi-natural IVF cycle for a BRCA1 gene mutation carrier. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 26-year-old patient with BRCA1 gene mutation. INTERVENTION(S): Semi-natural IVF cycle and intracytoplasmic sperm injection. MAIN OUTCOME MEASURE(S): Pregnancy rate. RESULT(S): A modified natural IVF cycle was performed, resulting in pregnancy and delivery. CONCLUSION(S): A modified natural IVF cycle is an effective and safe solution for BRCA1 or BRCA2 mutation gene carrier women with couple infertility. FAU - Hirt, Raphaël AU - Hirt R AD - Service de Gynécologie Obstétrique, Medecine de la Reproduction, Hôpital Cochin Port-Royal, Paris, France. FAU - Davy, Céline AU - Davy C FAU - Guibert, Juliette AU - Guibert J