• PMID: 15820831
• Gene Name: IGF1R
• Condition: Human sperm capacitation
• Association: The IGF-1 receptor was found in seminal plasma from fertile and infertile men, but no IGF-1 receptor was observed in sperm from patients with a history of more failed fertilization. The presence of the IGF-1 receptor in the plasma membrane of human sperm
• Sex: Male
• Infertility type: Male infertility
• Other associated phenotypes: Human sperm capacitation

Insulin growth factors may be implicated in human sperm capacitation

Sánchez-Luengo S, Fernández PJ, Romeu A.

This study was designed to determine whether or not insulin-like growth factor (IGF)-1 and its receptor are present in the human male genital tract. The IGF-1 receptor was found in seminal plasma from fertile and infertile men, but no IGF-1 receptor was observed in sperm from patients with a history of more failed fertilization. The presence of the IGF-1 receptor in the plasma membrane of human sperm is proposed as a future tool for male sterility assessment. FAU - Sánchez-Luengo, Silvia AU - Sánchez-Luengo S AD - Human Reproduction Department, Hospital la Fe, Avda Campanar 21, 46009 Valencia, Spain. sslvalencia@lycos.es FAU - Fernández, Pedro J AU - Fernández PJ