• PMID: 15380762
• Gene Name: ACR
• Condition: Non-obstructive azoospermic
• Association: Associated
• Population size: 95
• Population details: 95 non-obstructive azoospermic men
• Sex: Male
• Infertility type: Male infertility
• Associated genes: Proacrosin
• Other associated phenotypes: Non-obstructive azoospermic

[Proacrosin, an acrosomal marker for the detection of spermatogenic cells in ejaculates from azoospermic men]

Mitchell V, Brabant S, Koscinski I, Hermand E, Rigot JM.

Between January 2003 and April 2004, a prospective study was performed on ejaculates from non-obstructive azoospermic men (n = 95), for the identification of spermatogenic cells using an immunohistochemical labeling for proacrosin. 48.4% of ejaculates (46/95) displayed labeled spermatogenic cells. A 38/95 (40%) of men had testicular sperm extraction (TESE) followed by intracytoplasmic sperm injection (i.c.s.i.). Testicular spermatozoa were extracted from 21 men (52.5%). The sensitivity of detecting spermatogenic cells is 66.7% in predicting the presence of testicular spermatozoa, and its specificity is 76.5%. Compared to histopathological diagnostic testicular biopsy, the detection of spermatogenic cells using proacrosin immunohistochemical method offers a predictive parameter for successful TESE. The immunohistochemical method for proacrosin has the advantages of simplicity and low cost. It could be used to predict spermatogenesis from non-obstructive azoospermic men. Further evaluation is required with extensive results to improve sensitivity and specificity. FAU - Mitchell, V AU - Mitchell V AD - Unité fonctionnelle de spermiologie, hôpital Calmette, RDJ-1 Ouest, bd du Pr.-Jules-Leclerq, 59037 Lille, France. v-mitchell@chru-lille.fr FAU - Brabant, S AU - Brabant S FAU - Koscinski, I AU - Koscinski I FAU - Hermand, E AU - Hermand E