• Gene id: 9942

Gene Summary

• Gene Symbol: XYLB   Gene   UCSC   Ensembl
• Gene name: xylulokinase
• Alternate names: xylulose kinase, D-xylulokinase, xylulokinase homolog (H. influenzae),
• Gene location: 3p22.2 (38346759: 38453040)     Exons: 26     NC_000003.12
• Gene summary(Entrez): The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include f
• OMIM: 608259

Protein Summary

• Protein general information: O75191  
  • Name: Xylulose kinase (Xylulokinase) (EC 2.7.1.17)
  • Length: 536  
  • Mass: 58382
• Sequence:

  MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDII
  LEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLE
  AAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQ
  DKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG
  TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSKALQSTEMGNGGNLGF
  YFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKRIHAEGLGYRVMSKTKILATGGASHNREILQ
  VLADVFDAPVYVIDTANSACVGSAYRAFHGLAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQ
  RILSQTRGPPE

• Structural information:
  • Interpro: IPR000577  IPR018485  IPR018484  IPR042024  
  • CDD: cd07776
  • PDB: 4BC2 4BC3 4BC4 4BC5
  • PDBsum: 4BC2 4BC3 4BC4 4BC5
  • STRING: ENSP00000207870
• Other Databases: GeneCards:  XYLB  Malacards:  XYLB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004856	xylulokinase activity	IBA	molecular function
GO:0005829	cytosol	IBA	cellular component
GO:0005997	xylulose metabolic process	IBA	biological process
GO:0016310	phosphorylation	IBA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IBA	molecular function
GO:0004856	xylulokinase activity	IDA	molecular function
GO:0005997	xylulose metabolic process	IDA	biological process
GO:0004856	xylulokinase activity	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0042732	D-xylose metabolic process	IEA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0042732	D-xylose metabolic process	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0016310	phosphorylation	IEA	biological process
GO:0000166	nucleotide binding	IEA	molecular function
GO:0004856	xylulokinase activity	TAS	molecular function
GO:0005975	carbohydrate metabolic process	TAS	biological process
GO:0006091	generation of precursor metabolites and energy	TAS	biological process
GO:0004856	xylulokinase activity	IEA	molecular function
GO:0004856	xylulokinase activity	EXP	molecular function
GO:0019640	glucuronate catabolic process to xylulose 5-phosphate	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005998	xylulose catabolic process	TAS	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process
GO:0046835	carbohydrate phosphorylation	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00040	Pentose and glucuronate interconversions

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			16 (1 control, 15 cases)	Male infertility	GSE6023 analyzed using GEO2R