Male Infertility Database

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Gene id

9828

Gene Summary Protein Summary Gene ontology Diseases PubMed

Gene Summary

Gene Symbol

ARHGEF17 Gene UCSC Ensembl

Aliases

P164RHOGEF, RHOGEF17, TEM4, p164-RhoGEF

Gene name

Rho guanine nucleotide exchange factor 17

Alternate names

rho guanine nucleotide exchange factor 17, 164 kDa Rho-specific guanine-nucleotide exchange factor, Rho guanine nucleotide exchange factor (GEF) 17, Rho-specific guanine-nucleotide exchange factor 164 kDa, tumor endothelial marker 4,

Gene location

11q13.4 (73305960: 73369387) Exons: 24 NC_000011.10

OMIM

617335

Protein Summary

Protein general information

Q96PE2

Name: Rho guanine nucleotide exchange factor 17 (164 kDa Rho specific guanine nucleotide exchange factor) (p164 RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)

Length: 2063 Mass: 221673

Tissue specificity: Highly expressed in the heart. {ECO

Sequence

MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSKLASGPLAAPAQPRPL
RSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLFGGPGSRRPSADSESPGT
PSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQA
GARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS
LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKV
SFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGG
FEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAP
ASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE
KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSS
AQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEP
TGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKK
KSLSDPSRRGELAGPGFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH
RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEPP
TSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPAD
EPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHE
QFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ
ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHI
EGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKML
WKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQAL
CYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS
CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPP
ETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGT
LQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGS
LEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA
GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWV
TLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSP
GTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKML
VISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV

Structural information

Protein Domains	(1066..125-) (/note="DH-) (/evidence="ECO:0000255\|PROSITE-ProRule:PRU00062"-)
Interpro:	IPR039919 IPR039917 IPR035899 IPR000219 IPR011993 IPR015943 IPR036322
Prosite:	PS50010
CDD:	cd00160
MINT:
STRING:	ENSP00000263674

Other Databases

GeneCards: ARHGEF17 Malacards: ARHGEF17

Gene ontology

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GO accession	Term name	Evidence code	Go category
GO:0030036	actin cytoskeleton organi zation	IBA	biological process
GO:0005089	Rho guanyl-nucleotide exc hange factor activity	IBA	molecular function
GO:0005085	guanyl-nucleotide exchang e factor activity	IBA	molecular function
GO:0005085	guanyl-nucleotide exchang e factor activity	IEA	molecular function
GO:0005089	Rho guanyl-nucleotide exc hange factor activity	IEA	molecular function
GO:0005085	guanyl-nucleotide exchang e factor activity	IEA	molecular function
GO:0030036	actin cytoskeleton organi zation	IDA	biological process
GO:0005085	guanyl-nucleotide exchang e factor activity	IDA	molecular function
GO:0007186	G protein-coupled recepto r signaling pathway	TAS	biological process
GO:0043065	positive regulation of ap optotic process	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0051056	regulation of small GTPas e mediated signal transdu ction	TAS	biological process
GO:0005515	protein binding	IPI	molecular function

Diseases

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Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200

PubMed references

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PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
21674046	Aberrant C pGs in Low Motility Sperm			18	Male infertility	GSE26881	Show abstract
28606200	Cryptorchi dism			Monozgotic twin s (1 control, I cwith cryptorc hidism)	Male infertility	MeDIP-Seq	Show abstract

Male Infertility knowledgebase

A repository with genes crucial for male fertility

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Gene Summary

Protein Summary

Gene ontology

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Diseases

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PubMed references

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Male Infertility knowledgebase

A repository with genes crucial for male fertility

Search Result

Gene Summary

Protein Summary

Gene ontology

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Diseases Expand All | Collapse All

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PubMed references

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Diseases

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