• Gene id: 9797

Gene Summary

• Gene Symbol: TATDN2   Gene   UCSC   Ensembl
• Gene name: TatD DNase domain containing 2
• Alternate names: putative deoxyribonuclease TATDN2,
• Gene location: 3p25.3 (10248458: 10281217)     Exons: 8     NC_000003.12
• OMIM: 600052

Protein Summary

• Protein general information: Q93075  
  • Name: Putative deoxyribonuclease TATDN2 (EC 3.1.21. )
  • Length: 761  
  • Mass: 85023
• Sequence:

  MASERGKVKHNWSSTSEGCPRKRSCLREPCDVAPSSRPAQRSASRSGGPSSPKRLKAQKEDDVACSRRLSWGSSR
  RRNNSSSSFSPHFLGPGVGGAASKGCLIRNTRGFLSSGGSPLRPANASLEEMASLEEEACSLKVDSKDSSHNSTN
  SEFAAEAEGQNDTIEEPNKVQKRKRDRLRDQGSTMIYLKAIQGILGKSMPKRKGEAATRAKPSAAEHPSHGEGPA
  RSEGPAKTAEGAARSVTVTAAQKEKDATPEVSMEEDKTVPERSSFYDRRVVIDPQEKPSEEPLGDRRTVIDKCSP
  PLEFLDDSDSHLEIQKHKDREVVMEHPSSGSDWSDVEEISTVRFSQEEPVSLKPSAVPEPSSFTTDYVMYPPHLY
  SSPWCDYASYWTSSPKPSSYPSTGSSSNDAAQVGKSSRSRMSDYSPNSTGSVQNTSRDMEASEEGWSQNSRSFRF
  SRSSEEREVKEKRTFQEEMPPRPCGGHASSSLPKSHLEPSLEEGFIDTHCHLDMLYSKLSFQGTFTKFRKIYSSS
  FPKEFQGCISDFCDPRTLTDCLWEELLKEDLVWGAFGCHPHFARYYSESQERNLLQALRHPKAVAFGEMGLDYSY
  KCTTPVPEQHKVFERQLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMS
  VGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVREIARVKDQPLSLTLAA
  LRENTSRLYSL

• Structural information:
  • Interpro: IPR018228  IPR032466  IPR001130  
  • Prosite: PS01137 PS01090 PS01091
  • CDD: cd01310
  • STRING: ENSP00000287652
• Other Databases: GeneCards:  TATDN2  Malacards:  TATDN2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016788	hydrolase activity, acting on ester bonds	IEA	molecular function
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0036498	IRE1-mediated unfolded protein response	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0006259	DNA metabolic process	IEA	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881