• Gene id: 9692

Gene Summary

• Gene Symbol: PRORP   Gene   UCSC   Ensembl
• Aliases: KIAA0391, MRPP3
• Gene name: protein only RNase P catalytic subunit
• Alternate names: mitochondrial ribonuclease P catalytic subunit, mitochondrial RNase P protein 3, mitochondrial RNase P subunit 3, mitochondrial ribonuclease P protein 3, proteinaceous RNase P,
• Gene location: 14q13.2 (35122302: 35277621)     Exons: 12     NC_000014.9
• OMIM: 609947

Protein Summary

• Protein general information: O15091  
  • Name: Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit)
  • Length: 583  
  • Mass: 67315
• Sequence:

  MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSN
  KQVYSVPHFFLAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAG
  CHSSIDVAKSLLAWVAAKNNGIVSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDR
  WREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNK
  LLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQLSPEEYECLKGKIMRD
  VIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLLLNVVSQLAKRNLRLLVLGRKHMLR
  RSSQWSRDEMEEVQKQASCFFADDISEDDPFLLYATLHSGNHCRFITRDLMRDHKACLPDAKTQRLFFKWQQGHQ
  LAIVNRFPGSKLTFQRILSYDTVVQTTGDSWHIPYDEDLVERCSCEVPTKWLCLHQKT

• Structural information:
  • Protein Domains: (342..57-)
    (/note="PRORP"-)
  • Interpro: IPR033495  IPR031595  IPR011990  
  • PDB: 4ROU 4XGL 4XGM
  • PDBsum: 4ROU 4XGL 4XGM
  • STRING: ENSP00000440915
• Other Databases: GeneCards:  PRORP  Malacards:  PRORP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004526	ribonuclease P activity	IBA	molecular function
GO:0001682	tRNA 5'-leader removal	IBA	biological process
GO:0042645	mitochondrial nucleoid	IBA	cellular component
GO:0097745	mitochondrial tRNA 5'-end processing	IDA	biological process
GO:0030678	mitochondrial ribonuclease P complex	IDA	cellular component
GO:0004526	ribonuclease P activity	IDA	molecular function
GO:0008033	tRNA processing	IEA	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0008033	tRNA processing	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004518	nuclease activity	IEA	molecular function
GO:0005739	mitochondrion	IEA	cellular component
GO:0004526	ribonuclease P activity	IEA	molecular function
GO:0004526	ribonuclease P activity	EXP	molecular function
GO:0004526	ribonuclease P activity	EXP	molecular function
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0005759	mitochondrial matrix	TAS	cellular component
GO:0070901	mitochondrial tRNA methylation	TAS	biological process
GO:0070901	mitochondrial tRNA methylation	TAS	biological process
GO:0090646	mitochondrial tRNA processing	TAS	biological process
GO:0090646	mitochondrial tRNA processing	TAS	biological process
GO:0005739	mitochondrion	IEA	cellular component
GO:0005739	mitochondrion	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090501	RNA phosphodiester bond hydrolysis	IEA	biological process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	IEA	biological process
GO:0030678	mitochondrial ribonuclease P complex	TAS	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq