• Gene id: 9654

Gene Summary

• Gene Symbol: TTLL4   Gene   UCSC   Ensembl
• Gene name: tubulin tyrosine ligase like 4
• Alternate names: tubulin polyglutamylase TTLL4, tubulin tyrosine ligase-like family, member 4, tubulin--tyrosine ligase-like protein 4,
• Gene location: 2q35 (218710834: 218757483)     Exons: 5     NC_000002.12

Protein Summary

• Protein general information: Q14679  
  • Name: Tubulin polyglutamylase TTLL4 (EC 6. . . ) (Tubulin tyrosine ligase like protein 4)
  • Length: 1199  
  • Mass: 133378
• Sequence:

  MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQVETLSAGLGPGLLGVP
  PQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRRSSYRQKPYQQLESFCLRSSPSEKSPFSLPQ
  KSLPVSLTANKATSSMVFSMAQPMASSSTEPYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWP
  NSTPVPLLQTTQGLKPVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSV
  ASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQSSFLNPSFQWNVLNR
  SRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRISIHLLASHASGLNHNPACESVIDSSAFGEGK
  APGPPFPQTLGIANVATRLSSIQLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSR
  DENEEEEGDSECSSLSAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLP
  WEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLW
  RNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQR
  YLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANAD
  EMACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENL
  KPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLPTSPGDKCRMAPEHVT
  AQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSRYLRFFEQPRYFNILTT
  QWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLL
  LSEDGTTPKSKKTQAGLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP

• Structural information:
  • Protein Domains: (604..94-)
    (/note="TTL-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00568"-)
  • Interpro: IPR013815  IPR004344  IPR027748  
  • Prosite: PS51221
  • PDB: 5T6X
  • PDBsum: 5T6X
  • STRING: ENSP00000375951
• Other Databases: GeneCards:  TTLL4  Malacards:  TTLL4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070740	tubulin-glutamic acid ligase activity	IBA	molecular function
GO:0018095	protein polyglutamylation	IBA	biological process
GO:0015631	tubulin binding	IBA	molecular function
GO:0005929	cilium	IBA	cellular component
GO:0000226	microtubule cytoskeleton organization	IBA	biological process
GO:0018095	protein polyglutamylation	ISS	biological process
GO:0015631	tubulin binding	ISS	molecular function
GO:0070739	protein-glutamic acid ligase activity	ISS	molecular function
GO:0018200	peptidyl-glutamic acid modification	ISS	biological process
GO:0006464	cellular protein modification process	IEA	biological process
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005874	microtubule	IEA	cellular component
GO:0005929	cilium	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0016874	ligase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0018095	protein polyglutamylation	TAS	biological process
GO:0015631	tubulin binding	IEA	molecular function
GO:0018095	protein polyglutamylation	IEA	biological process
GO:0036064	ciliary basal body	IEA	cellular component
GO:0097731	9+0 non-motile cilium	IEA	cellular component
GO:0018200	peptidyl-glutamic acid modification	IEA	biological process
GO:0070739	protein-glutamic acid ligase activity	IEA	molecular function
GO:0005929	cilium	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881