• Gene id: 9524

Gene Summary

• Gene Symbol: TECR   Gene   UCSC   Ensembl
• Aliases: GPSN2, MRT14, SC2, TER
• Gene name: trans-2,3-enoyl-CoA reductase
• Alternate names: very-long-chain enoyl-CoA reductase, epididymis secretory sperm binding protein, glycoprotein, synaptic 2, synaptic glycoprotein SC2,
• Gene location: 19p13.12 (14527751: 14565979)     Exons: 18     NC_000019.10
• Gene summary(Entrez): This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This prote
• OMIM: 610057

Protein Summary

• Protein general information: Q9NZ01  
  • Name: Very long chain enoyl CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans 2,3 enoyl CoA reductase) (TER)
  • Length: 308  
  • Mass: 36034
  • Tissue specificity: Expressed in most tissues tested. Highly expressed in skeletal muscle. {ECO
• Sequence:

  MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTAT
  LYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHR
  FSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKT
  RKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLR
  MPIIPFLL

• Structural information:
  • Interpro: IPR001104  IPR039357  IPR029071  
  • Prosite: PS50244
  • PDB: 2DZJ
  • PDBsum: 2DZJ
  • STRING: ENSP00000215567
• Other Databases: GeneCards:  TECR  Malacards:  TECR

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0042761	very long-chain fatty acid biosynthetic process	IBA	biological process
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0102758	very-long-chain enoyl-CoA reductase activity	IMP	molecular function
GO:0006665	sphingolipid metabolic process	IMP	biological process
GO:0042761	very long-chain fatty acid biosynthetic process	IMP	biological process
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	IEA	molecular function
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0006665	sphingolipid metabolic process	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0006629	lipid metabolic process	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0006631	fatty acid metabolic process	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0102758	very-long-chain enoyl-CoA reductase activity	IEA	molecular function
GO:0005789	endoplasmic reticulum membrane	TAS	cellular component
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0006633	fatty acid biosynthetic process	IEA	biological process
GO:0006665	sphingolipid metabolic process	IEA	biological process
GO:0030176	integral component of endoplasmic reticulum membrane	IDA	cellular component
GO:0042761	very long-chain fatty acid biosynthetic process	IDA	biological process
GO:0030497	fatty acid elongation	IDA	biological process
GO:0005634	nucleus	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa01212	Fatty acid metabolism
hsa01040	Biosynthesis of unsaturated fatty acids
hsa00062	Fatty acid elongation

Diseases

Associated diseases	References
Autosomal recessive mental retardation	KEGG:H00768
Autosomal recessive mental retardation	KEGG:H00768
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Hypospermatogenesis	MIK: 28361989
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray