• Gene id: 94026

Gene Summary

• Gene Symbol: POM121L2   Gene   UCSC   Ensembl
• Aliases: POM121-L, POM121L
• Gene name: POM121 transmembrane nucleoporin like 2
• Alternate names: POM121-like protein 2, OM121 membrane glycoprotein (rat homolog)-like 2, POM121 membrane glycoprotein (rat homolog)-like 2, POM121 membrane glycoprotein-like 2,
• Gene location: 6p22.1 (27312231: 27309062)     Exons: 8     NC_000006.12

Protein Summary

• Protein general information: Q96KW2  
  • Name: POM121 like protein 2
  • Length: 1035  
  • Mass: 109912
• Sequence:

  MGSFLSKLELSPSSPAQVRTDLPERPTKRRPPQPLHQVHRVQFVHRAHPAPRYRPVRRRPNLDPANPTTWLANEA
  WRRFPMKKSQNSPLGPLPSDWWESYLKRTIWSLRHPRPIWSPVTIRITPPDQRVPPSTSPEDVIALAGLPPSEEL
  ADPCSKETVLRALRECRKGKGRLEEPLFPESLDSKRRSPETRPSAFKPLMKNGTLTSFVPRPGPLKRSLHSWGSD
  HSLTKRPNCSSMSSLASIYRGGTLSSKRNAIGSSYSSCRNFSDPWKRSVPSVSFETPEWPIKKEKSCHRPSSPVP
  LVSDFESLGGSESSGQQNQKIPQLPSSPENLVSEIPPPQLGYAVSDENLTLGKKAELQVSNNAGEDTTEVNTDPF
  PETWLAIQPSLSLALPSSETDLTQGANPQLENLRKMQKSLGPLASPQSTGEATSVAHSPLKTPSLPTPPGCSQSE
  LLPGTSPDSKPTATFILLTPTSPTLPVTDTTWPPSTSQADRSPMPPDPPAPPTIQSTLLGMVSSPTSHLSASAPP
  DATSAHLMLKPILGPLHNSEIGSSSYSRISVTAAASSISSLSTIQGTLTPTFKPIFGSIDPLKTTPMIAPFSSKQ
  TPPPFTHASTHHFHGLVKATSVVMSTTLASTSKDSVFKPPLDFGVVNVTSAVGNTYSVPSTCDTFLLGTAQAFRA
  DFTPATGFIFPPHHHPTIPTVHTVTMFTQVLSSVVQISPRSSTANFRGMGSPLPASALVSTNWLASTPSISNLTP
  AITSPLGSSSRPPFPLSQGANPQPAFGATNGQKQGPSQPALMPSVSSSFLFGSSAVALPTPMPTPAQPAFISTTQ
  SALGCLTPSASTSQTPASTWSGIGGIPAGFPISQASTTGFRIVIQTHQSGAFGSVFGSRAPQPFTFGGFVTPMDC
  DESGIIMTGPDMSPTSGAFSIGALPSGTTNTMIPFGKGWSQNTEGLPSHRTAFSLGRGSISARKTMAPIAQNTPV
  PGQAKAGSSVGFGMPFPPAQGSVGRGPFRSSASSFSIGAKSKTPKNREKGHSRRHHAYKK

• Structural information:
  • Interpro: IPR026054  
  • STRING: ENSP00000392726
• Other Databases: GeneCards:  POM121L2  Malacards:  POM121L2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005643	nuclear pore	IBA	cellular component
GO:0006405	RNA export from nucleus	IBA	biological process
GO:0008139	nuclear localization sequence binding	IBA	molecular function
GO:0017056	structural constituent of nuclear pore	IBA	molecular function
GO:0006606	protein import into nucleus	IBA	biological process

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray