• Gene id: 9398

Gene Summary

• Gene Symbol: CD101   Gene   UCSC   Ensembl
• Aliases: EWI-101, IGSF2, V7
• Gene name: CD101 molecule
• Alternate names: immunoglobulin superfamily member 2, cell surface glycoprotein V7, glu-Trp-Ile EWI motif-containing protein 101, leukocyte surface protein,
• Gene location: 1p13.1 (116987996: 117037480)     Exons: 12     NC_000001.11

Protein Summary

• Protein general information: Q93033  
  • Name: Immunoglobulin superfamily member 2 (IgSF2) (Cell surface glycoprotein V7) (Glu Trp Ile EWI motif containing protein 101) (EWI 101) (CD antigen CD101)
  • Length: 1021  
  • Mass: 115109
  • Tissue specificity: Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+
• Sequence:

  MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIIST
  KDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNLIVIPDTLSAT
  MSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLN
  KLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPL
  ELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAFSLKIFSLGPEDEGAY
  RCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNKQQVVWEGETLAFLCKAGGAESPLSVSWWHI
  PRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLS
  WTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGT
  IEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESK
  LKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQK
  FHTEKVSQDLFQLHILNVEDSDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVT
  EHREVAIRCSLESVGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVE
  MEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLL
  CLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN

• Structural information:
  • Protein Domains: (22..13-)
    1 (/note="Ig-like-C2-type)
    (144..26-)
    2 (/note="Ig-like-C2-type)
    (279..38-)
    3 (/note="Ig-like-C2-type)
    (408..52-)
    4 (/note="Ig-like-C2-type)
    (541..65-)
    5 (/note="Ig-like-C2-type)
    (656..79-)
    (/note="Ig-lik-)
  • Interpro: IPR002195  IPR007110  IPR036179  IPR013783  IPR013098   IPR003599  IPR013106  
  • Prosite: PS50835
  • STRING: ENSP00000358482
• Other Databases: GeneCards:  CD101  Malacards:  CD101

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016021	integral component of membrane	IBA	cellular component
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0016021	integral component of membrane	TAS	cellular component
GO:0002763	positive regulation of myeloid leukocyte differentiation	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881