• Gene id: 9317

Gene Summary

• Gene Symbol: PTER   Gene   UCSC   Ensembl
• Aliases: HPHRP, RPR-1
• Gene name: phosphotriesterase related
• Alternate names: phosphotriesterase-related protein, parathion hydrolase-related protein, resiniferatoxin-binding, phosphotriesterase-related,
• Gene location: 10p13 (16436942: 16517961)     Exons: 10     NC_000010.11
• OMIM: 604446

Protein Summary

• Protein general information: Q96BW5  
  • Name: Phosphotriesterase related protein (EC 3.1. . ) (Parathion hydrolase related protein) (hPHRP)
  • Length: 349  
  • Mass: 39018
• Sequence:

  MSSLSGKVQTVLGLVEPSKLGRTLTHEHLAMTFDCCYCPPPPCQEAISKEPIVMKNLYWIQKNAYSHKENLQLNQ
  ETEAIKEELLYFKANGGGALVENTTTGISRDTQTLKRLAEETGVHIISGAGFYVDATHSSETRAMSVEQLTDVLM
  NEILHGADGTSIKCGIIGEIGCSWPLTESERKVLQATAHAQAQLGCPVIIHPGRSSRAPFQIIRILQEAGADISK
  TVMSHLDRTILDKKELLEFAQLGCYLEYDLFGTELLHYQLGPDIDMPDDNKRIRRVRLLVEEGCEDRILVAHDIH
  TKTRLMKYGGHGYSHILTNVVPKMLLRGITENVLDKILIENPKQWLTFK

• Structural information:
  • Interpro: IPR017947  IPR032466  IPR001559  
  • Prosite: PS01322 PS51347
  • CDD: cd00530
  • STRING: ENSP00000367239
• Other Databases: GeneCards:  PTER  Malacards:  PTER

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008270	zinc ion binding	IEA	molecular function
GO:0009056	catabolic process	IEA	biological process
GO:0016788	hydrolase activity, acting on ester bonds	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0030855	epithelial cell differentiation	IEP	biological process
GO:0003674	molecular_function	ND	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881