• Gene id: 93129

Gene Summary

• Gene Symbol: ORAI3   Gene   UCSC   Ensembl
• Aliases: TMEM142C
• Gene name: ORAI calcium release-activated calcium modulator 3
• Alternate names: protein orai-3, transmembrane protein 142C,
• Gene location: 16p11.2 (30949067: 30954937)     Exons: 2     NC_000016.10
• OMIM: 617200

Protein Summary

• Protein general information: Q9BRQ5  
  • Name: Protein orai 3 (Transmembrane protein 142C)
  • Length: 295  
  • Mass: 31499
  • Tissue specificity: Expressed in both naive and effector T helper cells with higher levels in effector cells. {ECO
• Sequence:

  MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFA
  MVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELA
  WGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPA
  CPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV

• Structural information:
  • Interpro: IPR012446  IPR030032  IPR038350  
  • DIP: 48945
  • STRING: ENSP00000322249
• Other Databases: GeneCards:  ORAI3  Malacards:  ORAI3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0002115	store-operated calcium entry	IBA	biological process
GO:0015279	store-operated calcium channel activity	IBA	molecular function
GO:0016020	membrane	IBA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0002115	store-operated calcium entry	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0070588	calcium ion transmembrane transport	IEA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04020	Calcium signaling pathway

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray