• Gene id: 92912

Gene Summary

• Gene Symbol: UBE2Q2   Gene   UCSC   Ensembl
• Gene name: ubiquitin conjugating enzyme E2 Q2
• Alternate names: ubiquitin-conjugating enzyme E2 Q2, E2 ubiquitin-conjugating enzyme Q2, ubiquitin carrier protein Q2, ubiquitin conjugating enzyme E2Q family member 2, ubiquitin-protein ligase Q2,
• Gene location: 15q24.2 (75843342: 75901077)     Exons: 17     NC_000015.10
• OMIM: 612501

Protein Summary

• Protein general information: Q8WVN8  
  • Name: Ubiquitin conjugating enzyme E2 Q2 (EC 2.3.2.23) (E2 ubiquitin conjugating enzyme Q2) (Ubiquitin carrier protein Q2) (Ubiquitin protein ligase Q2)
  • Length: 375  
  • Mass: 42818
  • Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium. {ECO
• Sequence:

  MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPQQGSPHSLPPPLTLHCNITESYPSSSPIWFVDSE
  DPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEMLDQPLPTGQNGTTEEVTSEEEEEEEEMAED
  IEDLDHYEMKEEEPISGKKSEDEGIEKENLAILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTG
  IYSVELINDSLYDWHVKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGG
  GALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQIHEKNGWYTPPKEDG

• Structural information:
  • Interpro: IPR000608  IPR016135  
  • Prosite: PS50127
  • CDD: cd00195
  • PDB: 1ZUO
  • PDBsum: 1ZUO
  • STRING: ENSP00000267938
• Other Databases: GeneCards:  UBE2Q2  Malacards:  UBE2Q2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0070936	protein K48-linked ubiquitination	IBA	biological process
GO:0000209	protein polyubiquitination	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IBA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0016567	protein ubiquitination	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0061631	ubiquitin conjugating enzyme activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016567	protein ubiquitination	IEA	biological process
GO:0070936	protein K48-linked ubiquitination	IDA	biological process
GO:0004842	ubiquitin-protein transferase activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04120	Ubiquitin mediated proteolysis

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)