• Gene id: 92342

Gene Summary

• Gene Symbol: METTL18   Gene   UCSC   Ensembl
• Aliases: AsTP2, C1orf156, HPM1
• Gene name: methyltransferase like 18
• Alternate names: histidine protein methyltransferase 1 homolog, arsenic-transactivated protein 2, methyltransferase-like protein 18,
• Gene location: 1q24.2 (169794906: 169792523)     Exons: 3     NC_000001.11
• OMIM: 615255

Protein Summary

• Protein general information: O95568  
  • Name: Histidine protein methyltransferase 1 homolog (EC 2.1.1. ) (Arsenic transactivated protein 2) (AsTP2) (Methyltransferase like protein 18)
  • Length: 372  
  • Mass: 42148
• Sequence:

  MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDT
  DSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKS
  FSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDE
  VTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPD
  YYSNLHQTFLRLLSKNGRVLLASKAHYFGVGGGVHLFQKFVEERDVFKTRILKIIDEGLKRFIIEITFKFPG

• Structural information:
  • Interpro: IPR029063  
  • PDB: 4RFQ
  • PDBsum: 4RFQ
  • STRING: ENSP00000307975
• Other Databases: GeneCards:  METTL18  Malacards:  METTL18

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008168	methyltransferase activity	IBA	molecular function
GO:0018064	protein-histidine N-methyltransferase activity	IBA	molecular function
GO:0032259	methylation	IBA	biological process
GO:0042038	peptidyl-histidine methylation, to form tele-methylhistidine	IBA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0032991	protein-containing complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0008150	biological_process	ND	biological process
GO:0031072	heat shock protein binding	IPI	molecular function
GO:0031072	heat shock protein binding	IPI	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881