|
Gene id |
9232 |
| Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
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Gene Symbol |
PTTG1 Gene UCSC Ensembl |
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Aliases |
EAP1, HPTTG, PTTG, TUTR1 |
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Gene name |
PTTG1 regulator of sister chromatid separation, securin |
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Alternate names |
securin, ESP1-associated protein 1, pituitary tumor-transforming 1, pituitary tumor-transforming gene 1 protein, tumor-transforming protein 1, |
|
Gene location |
5q33.3 (160421854: 160428743) Exons: 6 NC_000005.10
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|
Gene summary(Entrez) |
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product
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OMIM |
604147 |
Protein Summary
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| GO accession | Term name | Evidence code | Go category |
|---|
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| Associated diseases |
References |
| Ovarian insufficiency | INFBASE: 24418349 |
| Aberrant CpGs in Low Motility Sperm | MIK: 21674046 |
| Male infertility | MIK: 26404029 |
| Teratozoospermia | MIK: 17327269 |
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| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 26404029 |
May contri
bute to oc
currence a
nd develop
ment of te
ratozoospe
rmia, Male
infertili
ty
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 21674046 |
Aberrant C
pGs in Low
Motility
Sperm
|
|
|
18
|
Male infertility |
GSE26881
|
Show abstract |
|