• Gene id: 92181

Gene Summary

• Gene Symbol: UBTD2   Gene   UCSC   Ensembl
• Aliases: DCUBP
• Gene name: ubiquitin domain containing 2
• Alternate names: ubiquitin domain-containing protein 2, ubiquitin-like protein SB72,
• Gene location: 5q35.1 (172283796: 172209644)     Exons: 4     NC_000005.10
• OMIM: 610174

Protein Summary

• Protein general information: Q8WUN7  
  • Name: Ubiquitin domain containing protein 2 (Dendritic cell derived ubiquitin like protein) (DC UbP) (Ubiquitin like protein SB72)
  • Length: 234  
  • Mass: 26190
  • Tissue specificity: Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues. {ECO
• Sequence:

  MGGCVGAQHDSSGSLNENSEGTGVALGRNQPLKKEKPKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALK
  AAAHAFESNDHELAQAIIDGANITLPHGALTECYDELGNRYQLPVYCLAPPINMIEEKSDIETLDIPEPPPNSGY
  ECQLRLRLSTGKDLKLVVRSTDTVFHMKRRLHAAEGVEPGSQRWFFSGRPLTDKMKFEELKIPKDYVVQVIVSQP
  VQNPTPVEN

• Structural information:
  • Protein Domains: (152..22-)
    (/note="Ubiquitin-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00214"-)
  • Interpro: IPR032752  IPR038169  IPR000626  IPR029071  IPR039869  
  • Prosite: PS50053
  • PDB: 1TTN 2KSN
  • PDBsum: 1TTN 2KSN
  • STRING: ENSP00000377381
• Other Databases: GeneCards:  UBTD2  Malacards:  UBTD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray