• Gene id: 91584

Gene Summary

• Gene Symbol: PLXNA4   Gene   UCSC   Ensembl
• Aliases: FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003
• Gene name: plexin A4
• Alternate names: plexin-A4, epididymis secretory sperm binding protein,
• Gene location: 7q32.3 (132648687: 132123331)     Exons: 40     NC_000007.14
• OMIM: 604280

Protein Summary

• Protein general information: Q9HCM2  
  • Name: Plexin A4
  • Length: 1894  
  • Mass: 212455
• Sequence:

  MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLS
  SDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLG
  EPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVAS
  MIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC
  ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCY
  RGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGT
  KSGKLKKIRVDGPRGNALQYETVQVVDPGPVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDP
  HCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLVLETYNVPELSAGVNCTFEDLSE
  MDGLVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVESPYRCHWC
  KYRHVCTHDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQGSEQRV
  PALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKADPDFACGW
  CQGPGQCTLRQHCPAQESQWLELSGAKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVE
  CSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLKPSRGPMSGGTQVTIT
  GTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVSVQVDRAKIHQDLVFQYVEDPTIVRIEPEWS
  IVSGNTPIAVWGTHLDLIQNPQIRAKHGGKEHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNV
  QSLLILNKTNFTYYPNPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLL
  CESPNLIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQ
  MQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYRQERVEK
  GLKLFAQLINNKVFLLSFIRTLESQRSFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKL
  LLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTL
  VLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSGARMILQDEDITTKIE
  NDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASKYENMIRYTGSPDSLRSRTPMITPDLESGVK
  MWHLVKNHEHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQAD
  KHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLY
  AKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKYSEEILGPLDHDDQCG
  KQKLAYKLEQVITLMSLDS

• Structural information:
  • Protein Domains: (24..50-)
    (/note="Sema-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00352-)
    (509..55-)
    (/note="PSI-1)
    (655..70-)
    (/note="PSI-2)
    (803..85-)
    (/note="PSI-3)
    (858..95-)
    (/note="IPT/TIG-1)
    (954..103-)
    (/note="IPT/TIG-2";)
  • Interpro: IPR013783  IPR014756  IPR002909  IPR031148  IPR013548   IPR002165  IPR016201  IPR008936  IPR001627  IPR036352  IPR041019  IPR041362  IPR015943  
  • Prosite: PS51004
  • PDB: 3999 9999 9999 9999 8065 9275 2472 1116 8791 5407 8436 3212 0534 2066 8827 2790 5460 0142 848
  • PDBsum: 3999 9999 9999 9999 8065 9275 2472 1116 8791 5407 8436 3212 0534 2066 8827 2790 5460 0142 848
  • STRING: ENSP00000352882
• Other Databases: GeneCards:  PLXNA4  Malacards:  PLXNA4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008360	regulation of cell shape	IBA	biological process
GO:0030334	regulation of cell migration	IBA	biological process
GO:0050772	positive regulation of axonogenesis	IBA	biological process
GO:0002116	semaphorin receptor complex	IBA	cellular component
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007162	negative regulation of cell adhesion	IBA	biological process
GO:0017154	semaphorin receptor activity	IBA	molecular function
GO:0043087	regulation of GTPase activity	IBA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IBA	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0048841	regulation of axon extension involved in axon guidance	IEA	biological process
GO:0021784	postganglionic parasympathetic fiber development	IEA	biological process
GO:0021644	vagus nerve morphogenesis	IEA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IEA	biological process
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0050923	regulation of negative chemotaxis	IEA	biological process
GO:0048812	neuron projection morphogenesis	IEA	biological process
GO:0048485	sympathetic nervous system development	IEA	biological process
GO:0021960	anterior commissure morphogenesis	IEA	biological process
GO:0021793	chemorepulsion of branchiomotor axon	IEA	biological process
GO:0021785	branchiomotor neuron axon guidance	IEA	biological process
GO:0021637	trigeminal nerve structural organization	IEA	biological process
GO:0021636	trigeminal nerve morphogenesis	IEA	biological process
GO:0021615	glossopharyngeal nerve morphogenesis	IEA	biological process
GO:0021612	facial nerve structural organization	IEA	biological process
GO:0021610	facial nerve morphogenesis	IEA	biological process
GO:0021602	cranial nerve morphogenesis	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0008045	motor neuron axon guidance	IEA	biological process
GO:0007411	axon guidance	IEA	biological process
GO:0007399	nervous system development	IEA	biological process
GO:0002116	semaphorin receptor complex	TAS	cellular component
GO:0071526	semaphorin-plexin signaling pathway	NAS	biological process
GO:0005886	plasma membrane	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq