• Gene id: 91304

Gene Summary

• Gene Symbol: TMEM259   Gene   UCSC   Ensembl
• Aliases: ASBABP1, C19orf6, MBRL, MEMBRALIN, R32184_3
• Gene name: transmembrane protein 259
• Alternate names: membralin, aspecific BCL2 ARE-binding protein 1,
• Gene location: 19p13.3 (1021141: 1009650)     Exons: 12     NC_000019.10
• OMIM: 611011

Protein Summary

• Protein general information: Q4ZIN3  
  • Name: Membralin (Transmembrane protein 259)
  • Length: 620  
  • Mass: 67889
• Sequence:

  MSEHVEPAAPGPGPNGGGGGPAPARGPRTPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLK
  ALFVLFVLAYIHIVFSRSPINCLEHVRDKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDM
  EDEEEEELTMEMFGNSSIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYGFLRLSQA
  TRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMA
  RTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTT
  TAFYIILIVWLADQYDAICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYE
  LPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPGASGSPGPVAAAPSSLVA
  AAASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRPASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAA
  VGGPSPASMAPTEAPSEVGS

• Structural information:
  • Interpro: IPR019144  
  • STRING: ENSP00000349087
• Other Databases: GeneCards:  TMEM259  Malacards:  TMEM259

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005783	endoplasmic reticulum	IBA	cellular component
GO:1904294	positive regulation of ERAD pathway	IBA	biological process
GO:0034976	response to endoplasmic reticulum stress	IBA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:1904294	positive regulation of ERAD pathway	IEA	biological process
GO:1901215	negative regulation of neuron death	IEA	biological process
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0034976	response to endoplasmic reticulum stress	IEA	biological process
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq